Gurung Tikaram, Singh R K, Mohammad Shadab, Pal U S, Mahdi Abbas Ali, Kumar Manoj
Department of Oral and Maxillofacial Surgery, KGMU, Lucknow, Uttar Pradesh, India.
Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India.
Natl J Maxillofac Surg. 2017 Jan-Jun;8(1):41-49. doi: 10.4103/njms.NJMS_84_16.
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease characterized by deterioration of articular tissue with concomitant osseous changes in the condyle and/or articular eminence, joint positive for TMJ noise with jaw movement or function, crepitus detected on palpation on opening, closing, right/left lateral, or protrusive movement. Hyaluronic acid (HA) is a polysaccharide of the family of glycosaminoglycans. HA has been shown to improve and restore normal lubrication in joint, provide nutrition to the avascular articulating disc, and stabilize the joint.
Twenty patients with OA of TMJ with age limit between 18 and 60 years of age were enrolled in this study. Patients were randomly divided into two groups, in which one group received arthrocentesis only, and another group received arthrocentesis plus intra-articular injection of sodium HA (0.5 ml) in superior joint space in a cycle of 5 weekly arthrocentesis (one per week). Patients were followed at regular interval of 1 day, 5 day, 7 day, 4 weeks, 6 weeks, and 12 weeks. Assessment of clinical outcome was done in terms of reduction in pain (visual analog scale score), maximum mouth opening (MMO) in millimeters, painful/pain-free lateral or protrusive jaw movement, and clicking/crepitus in joint.
Significant reduction in pain was observed in both the groups. MMO, lateral and protrusive movements improved significantly in both groups; however, arthrocentesis with sodium HA was superior to arthrocentesis alone.
Combination of arthrocentesis with HA injection showed much better outcome than arthrocentesis alone.
颞下颌关节骨关节炎(TMJ OA)是一种退行性疾病,其特征为关节组织退化,同时髁突和/或关节结节出现骨质改变,下颌运动或功能时关节出现TMJ杂音阳性,开口、闭口、左右侧方或前伸运动触诊时可检测到摩擦音。透明质酸(HA)是糖胺聚糖家族的一种多糖。已证明HA可改善和恢复关节的正常润滑,为无血管的关节盘提供营养,并稳定关节。
本研究纳入了20例年龄在18至60岁之间的TMJ OA患者。患者被随机分为两组,一组仅接受关节穿刺,另一组接受关节穿刺并在关节上腔注射0.5 ml HA钠,每周进行一次关节穿刺,共5周为一个周期。定期在第1天、第5天、第7天、第4周、第6周和第12周对患者进行随访。根据疼痛减轻程度(视觉模拟量表评分)、最大开口度(以毫米为单位)、疼痛/无痛的侧方或前伸下颌运动以及关节弹响/摩擦音来评估临床结果。
两组患者的疼痛均显著减轻。两组患者的最大开口度、侧方和前伸运动均有显著改善;然而,HA钠关节穿刺优于单纯关节穿刺。
关节穿刺联合HA注射的效果明显优于单纯关节穿刺。