• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease.

作者信息

Castillo Willian O, Aristizabal-Pachon Andres Felipe

机构信息

Department of Biology, University of Cauca, Popayan, Colombia.

Department of Genetics, Ribeirão Preto Medical School, University of São Paulo - USP, Brazil.

出版信息

Neural Regen Res. 2017 Jun;12(6):916-917. doi: 10.4103/1673-5374.208572.

DOI:10.4103/1673-5374.208572
PMID:28761423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5514865/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a553/5514865/c512ff3dfc97/NRR-12-916-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a553/5514865/c512ff3dfc97/NRR-12-916-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a553/5514865/c512ff3dfc97/NRR-12-916-g001.jpg

相似文献

1
Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease.加兰他敏在阿尔茨海默病模型中可防止β淀粉样肽诱导的DNA损伤。
Neural Regen Res. 2017 Jun;12(6):916-917. doi: 10.4103/1673-5374.208572.
2
Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons.加兰他敏可保护皮质神经元免受β-淀粉样肽诱导的氧化应激。
Eur J Neurosci. 2009 Feb;29(3):455-64. doi: 10.1111/j.1460-9568.2009.06612.x.
3
Galantamine alleviates senescence of U87 cells induced by beta-amyloid through decreasing ROS production.加兰他敏通过减少活性氧的产生减轻β-淀粉样蛋白诱导的U87细胞衰老。
Neurosci Lett. 2017 Jul 13;653:183-188. doi: 10.1016/j.neulet.2017.05.055. Epub 2017 May 26.
4
Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice.加兰他敏前药Memogain经鼻腔给药可减缓5XFAD小鼠的斑块沉积并改善其行为。
J Alzheimers Dis. 2015;46(1):123-36. doi: 10.3233/JAD-142421.
5
Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors.加兰他敏可预防β-淀粉样蛋白和毒胡萝卜素诱导的细胞凋亡:烟碱型乙酰胆碱受体的作用
Neuropharmacology. 2004 Jan;46(1):103-14. doi: 10.1016/s0028-3908(03)00317-4.
6
Investigating the binding interactions of galantamine with β-amyloid peptide.研究加兰他敏与β-淀粉样肽的结合相互作用。
Bioorg Med Chem Lett. 2013 Jan 1;23(1):239-43. doi: 10.1016/j.bmcl.2012.10.111. Epub 2012 Nov 10.
7
Galantamine inhibits calpain-calcineurin signaling activated by beta-amyloid in human neuroblastoma SH-SY5Y cells.加兰他敏抑制β淀粉样蛋白激活的人神经母细胞瘤 SH-SY5Y 细胞中的钙蛋白酶-钙调神经磷酸酶信号通路。
Neurosci Lett. 2010 Aug 23;480(3):173-7. doi: 10.1016/j.neulet.2010.06.005.
8
Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease.早给予加兰他敏可抑制阿尔茨海默病 APPswe/PS1dE9 小鼠模型的斑块前阶段的氧化应激并改善认知行为。
Free Radic Biol Med. 2019 Dec;145:20-32. doi: 10.1016/j.freeradbiomed.2019.09.014. Epub 2019 Sep 16.
9
Protective effects of galantamine against Abeta-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress.加兰他敏通过防止线粒体功能障碍和内质网应激预防 Abeta 诱导的 PC12 细胞凋亡的保护作用。
Neurochem Int. 2010 Nov;57(5):588-99. doi: 10.1016/j.neuint.2010.07.007. Epub 2010 Jul 22.
10
Chronic Cerebral Hypoperfusion Accelerates Alzheimer's Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model.在一种新型小鼠模型中,慢性脑灌注不足通过脑血管重塑加速阿尔茨海默病病理进程。
J Alzheimers Dis. 2016 Jun 13;53(3):893-905. doi: 10.3233/JAD-160345.

引用本文的文献

1
Imidazo[2,1-][1,3]thiazine Derivatives as Potential Modulators of Alpha-Synuclein Amyloid Aggregation.咪唑并[2,1-][1,3]噻嗪衍生物作为α-突触核蛋白淀粉样聚集的潜在调节剂
ACS Chem Neurosci. 2024 Dec 18;15(24):4418-4430. doi: 10.1021/acschemneuro.4c00451. Epub 2024 Nov 27.
2
Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents.天然膳食化合物作为抗阿尔茨海默病药物的遗传和表观遗传靶点
Neural Regen Res. 2024 Apr;19(4):846-854. doi: 10.4103/1673-5374.382232.
3
Sting and p53 DNA repair pathways are compromised in Alzheimer's disease.

本文引用的文献

1
Exploration of the Acetylcholinesterase Inhibitory Activity of Some Alkaloids from Amaryllidaceae Family by Molecular Docking In Silico.通过分子对接的计算机模拟探索石蒜科生物碱的乙酰胆碱酯酶抑制活性。
Neurochem Res. 2017 Oct;42(10):2826-2830. doi: 10.1007/s11064-017-2295-8. Epub 2017 May 11.
2
Galanthamine decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line.加兰他敏可降低β-淀粉样肽在SH-SY5Y细胞系中诱导的遗传毒性和细胞死亡。
Neurotoxicology. 2016 Dec;57:291-297. doi: 10.1016/j.neuro.2016.10.013. Epub 2016 Oct 25.
3
The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease.
在阿尔茨海默病中,Sting 和 p53 DNA 修复途径受损。
Sci Rep. 2023 May 23;13(1):8304. doi: 10.1038/s41598-023-35533-6.
4
High Methionine Diet-Induced Alzheimer's Disease like Symptoms Are Accompanied by 5-Methylcytosine Elevated Levels in the Brain.高蛋氨酸饮食诱导的阿尔茨海默病样症状伴随着大脑中 5-甲基胞嘧啶水平升高。
Behav Neurol. 2021 Apr 7;2021:6683318. doi: 10.1155/2021/6683318. eCollection 2021.
5
A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders.一种新型石杉碱甲-姜黄素杂合体作为神经退行性疾病潜在多靶点治疗药物。
Molecules. 2021 Mar 25;26(7):1865. doi: 10.3390/molecules26071865.
6
Tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl)carbamate Has Moderated Protective Activity in Astrocytes Stimulated with Amyloid Beta 1-42 and in a Scopolamine Model.叔丁基-(4-羟基-3-((3-(2-甲基哌啶基)丙基)氨基甲酰基)苯基)氨基甲酸酯对淀粉样蛋白β 1-42 刺激的星形胶质细胞和东莨菪碱模型具有适度的保护活性。
Molecules. 2020 Oct 29;25(21):5009. doi: 10.3390/molecules25215009.
7
Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway.氯胺酮的神经保护潜力可通过PI3K/AKT/GSK-3β信号通路预防异氟烷诱导的发育中脑结构损伤和神经认知功能改变。
Drug Des Devel Ther. 2019 Feb 4;13:501-512. doi: 10.2147/DDDT.S188636. eCollection 2019.
8
Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders.植物源性生物碱在神经退行性疾病中的作用及其机制。
Int J Biol Sci. 2018 Mar 9;14(3):341-357. doi: 10.7150/ijbs.23247. eCollection 2018.
神经元对氧化性DNA损伤的反应:机制与疾病
Neural Plast. 2016;2016:3619274. doi: 10.1155/2016/3619274. Epub 2016 Jan 31.
4
Therapeutic opportunities within the DNA damage response.DNA 损伤反应中的治疗机会。
Nat Rev Cancer. 2015 Mar;15(3):166-80. doi: 10.1038/nrc3891.
5
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.DNA聚合酶β缺乏会导致神经退行性变并加剧阿尔茨海默病的表型。
Nucleic Acids Res. 2015 Jan;43(2):943-59. doi: 10.1093/nar/gku1356. Epub 2014 Dec 30.
6
Therapeutics of Alzheimer's disease: Past, present and future.阿尔茨海默病治疗学:过去、现在和未来。
Neuropharmacology. 2014 Jan;76 Pt A:27-50. doi: 10.1016/j.neuropharm.2013.07.004. Epub 2013 Jul 25.
7
Antioxidant activity of galantamine and some of its derivatives.
Curr Med Chem. 2013;20(36):4595-608. doi: 10.2174/09298673113209990148.
8
Modulation of DNA base excision repair during neuronal differentiation.神经元分化过程中 DNA 碱基切除修复的调控。
Neurobiol Aging. 2013 Jul;34(7):1717-27. doi: 10.1016/j.neurobiolaging.2012.12.016. Epub 2013 Feb 1.
9
Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts.一些石蒜科生物碱和水仙提取物的乙酰胆碱酯酶抑制活性
Life Sci. 2002 Oct 11;71(21):2521-9. doi: 10.1016/s0024-3205(02)02034-9.