Jiang Peng, Zhang Zi Fang, Wang Zhong Quan, Liu Ruo Dan, Zhang Xi, Sun Ge Ge, Qi Xin, Wang Li, Cui Jing
Dept. of Parasitology, Medical College, Zhengzhou University, Zhengzhou, P. R. China.
Iran J Parasitol. 2017 Jan-Mar;12(1):130-135.
The intraperitoneal injection is a common method for establishing the experimental animal model infected with parasites. The aim of this study was to investigate if the intraperitoneal injection was another route of infection.
From June to July 2015, twenty BALB/c mice were intraperitoneally injected with 300 muscle larvae in Department of Parasitology, Medical College, Zhengzhou University, China. The larvae per gr (LPG) muscle from the infected mice and the reproductive capacity index (RCI) of were calculated.
Sixty percent (12/20) mice injected were successfully infected at 35 day post injection (dpi), but the muscle larval burden (381.53 larvae per gr) and reproductive capacity index (32.33) in infected mice was lower.
A mechanical force indicated as a possible mechanism in successful larval invasion of almost all kind of host tissues. However, the exact migratory route of larvae from peritoneal cavity into small intestine is not clear.
腹腔注射是建立寄生虫感染实验动物模型的常用方法。本研究的目的是调查腹腔注射是否为另一种感染途径。
2015年6月至7月，在中国郑州大学医学院寄生虫学系，给20只BALB/c小鼠腹腔注射300条肌幼虫。计算感染小鼠每克肌肉中的幼虫数（LPG）和繁殖能力指数（RCI）。
注射后35天，60%（12/20）的注射小鼠成功感染，但感染小鼠的肌肉幼虫负荷（每克381.53条幼虫）和繁殖能力指数（32.33）较低。
一种机械力被认为是几乎所有类型宿主组织中幼虫成功侵入的可能机制。然而，幼虫从腹腔进入小肠的确切迁移途径尚不清楚。
