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首例报道的后弹力层内皮角膜移植术后供体相关念珠菌性眼内炎病例。

First Reported Case of Donor Related Candida Endophthalmitis after Descemet Membrane Endothelial Keratoplasty.

作者信息

Thompson Matthew, Carli David

机构信息

Tower Clock Eye Center 1087 W Mason St. Green Bay, WI, 54303, USA.

Medical Student Des Moines University, 3200 Grand Ave Des Moines, IA 50312, USA.

出版信息

Open Ophthalmol J. 2017 Jun 19;11:117-121. doi: 10.2174/1874364101711010117. eCollection 2017.

DOI:10.2174/1874364101711010117
PMID:28761565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5510561/
Abstract

PURPOSE

To report the first case of Candida donor to host transmission following descemet membrane endothelial keratoplasty (DMEK).

METHODS

A retrospective case report.

RESULTS

A patient underwent uneventful DMEK. Following surgery the donor rim was culture positive for Candida. The patient developed fungal endophthalmitis that was treated medically with multiple injections of voriconazole and amphotericin. Medical treatment was unable to clear the infection and removal of the donor material was required. Following removal the infection subsided.

CONCLUSION

Candida interface keratitis and endophthalmitis can occur following DMEK and may be difficult to treat medically. Early removal of the donor material should be considered.

摘要

目的

报告首例在Descemet膜内皮角膜移植术（DMEK）后发生的念珠菌供体到宿主传播病例。

方法

一项回顾性病例报告。

结果

一名患者接受了顺利的DMEK手术。术后供体边缘念珠菌培养呈阳性。患者发生真菌性眼内炎，通过多次注射伏立康唑和两性霉素进行药物治疗。药物治疗无法清除感染，需要移除供体材料。移除后感染消退。

结论

DMEK术后可发生念珠菌性界面角膜炎和眼内炎，药物治疗可能困难。应考虑早期移除供体材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbf4/5510561/0851c1c4c8a5/TOOPHTJ-11-117_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbf4/5510561/0851c1c4c8a5/TOOPHTJ-11-117_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbf4/5510561/0851c1c4c8a5/TOOPHTJ-11-117_F1.jpg

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PLoS Pathog. 2016 Mar 30;12(3):e1005522. doi: 10.1371/journal.ppat.1005522. eCollection 2016 Mar.
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供体真菌培养阳性的内皮角膜移植术后迟发性真菌性界面角膜炎
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Br J Ophthalmol. 2019 Mar;103(3):307-314. doi: 10.1136/bjophthalmol-2018-312938. Epub 2018 Oct 24.
在角膜后弹力层剥除自动内皮角膜移植术后，光滑念珠菌性眼内炎从移植物传播至宿主。
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