Karimov Jamshid H, Gao Shengqiang, Dessoffy Raymond, Sunagawa Gengo, Sinkewich Martin, Grady Patrick, Sale Shiva, Moazami Nader, Fukamachi Kiyotaka
Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Medical Device Solutions, Cleveland Clinic, Cleveland, OH, USA.
J Artif Organs. 2017 Dec;20(4):386-389. doi: 10.1007/s10047-017-0976-3. Epub 2017 Jul 31.
Successful implantation of a total artificial heart relies on multiple standardized procedures, primarily the resection of the native heart, and exacting preparation of the atrial and vascular conduits for pump implant and activation. Achieving secure pump connections to inflow/outflow conduits is critical to a successful outcome. During the connection process, however, air may be introduced into the circulation, traveling to the brain and multiple organs. Such air emboli block blood flow to these areas and are detrimental to long-term survival. A correctly managed pump-to-conduit connection prevents air from collecting in the pump and conduits. To further optimize pump-connection techniques, we have developed a novel connecting sleeve that enables airless connection of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) to the conduits. In this brief report, we describe the connecting sleeve design and our initial results from two acute in vivo implantations using a scaled-down version of the CFTAH.
全人工心脏的成功植入依赖于多个标准化程序，主要是切除天然心脏，以及为泵植入和启动精确准备心房和血管导管。实现泵与流入/流出导管的安全连接对于成功结果至关重要。然而，在连接过程中，空气可能会进入循环系统，流向大脑和多个器官。这种空气栓子会阻塞这些区域的血流，对长期生存有害。正确管理泵与导管的连接可防止空气在泵和导管中积聚。为了进一步优化泵连接技术，我们开发了一种新型连接套筒，可实现克利夫兰诊所连续流全人工心脏（CFTAH）与导管的无气连接。在本简要报告中，我们描述了连接套筒的设计以及使用CFTAH缩小版进行的两次急性体内植入的初步结果。
