Department of Clinical and Experimental Medicine, Medical School, University of Catania, Internal Medicine Division, G. Rodolico University Hospital, Catania, Italy.
Second Department of Propaedeutic Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
Curr Vasc Pharmacol. 2018;16(6):547-554. doi: 10.2174/1570161115666170731165121.
Peripheral Artery Disease (PAD), a common vascular disease, has been associated with increased Cardiovascular (CV) morbidity and mortality as well as all-cause death. Type 2 Diabetes Mellitus (T2DM) predisposes to PAD development. In T2DM patients, PAD further increases the risk for CV disease and death as well as foot morbidity and microvascular complications. The present narrative review discusses the role of oxidative stress and inflammation in the pathophysiology of PAD with or without the presence of T2DM. The effects of lifestyle measures (i.e. diet, physical activity and smoking cessation) and drug treatment on markers of oxidative stress and inflammation are also considered. Further research should establish the clinical implications of such effects as well as the clinical use of antioxidants and anti-inflammatory drugs in PAD.
外周动脉疾病（PAD）是一种常见的血管疾病，与心血管（CV）发病率和死亡率以及全因死亡增加有关。2 型糖尿病（T2DM）易患 PAD。在 T2DM 患者中，PAD 进一步增加了 CV 疾病和死亡以及足部发病率和微血管并发症的风险。本叙述性综述讨论了氧化应激和炎症在外周动脉疾病（PAD）发病机制中的作用，无论是否存在 2 型糖尿病（T2DM）。还考虑了生活方式措施（即饮食、体育活动和戒烟）和药物治疗对氧化应激和炎症标志物的影响。进一步的研究应确定这些影响的临床意义，以及抗氧化剂和抗炎药物在 PAD 中的临床应用。
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