Zheng Lei, Zhao Biao, Zhang Zhenxi, Liu Yutong, Zhang Yingying, Cai Jing, Qiao Tong
Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing 210008, China.
Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing 210008, China.
Pharmaceuticals (Basel). 2024 Nov 25;17(12):1583. doi: 10.3390/ph17121583.
: Chronic Limb-Threatening Ischemia (CLTI) is a chronic limb ischemic disease caused by vascular lesions, characterized by pain, ulcers, and gangrene, which can be life-threatening in severe cases. The objective of this study is to explore whether Berbamine (BBM) can protect against and repair ischemic muscle tissue in the lower limbs; : Using a mouse hindlimb ischemia (HLI) model, 36 C57BL6 mice were divided into sham, HLI, and HLI+BBM treatment groups. : Our findings indicate that BBM can restore motor function and muscle tissue pathology in mice, potentially by inhibiting the nuclear translocation of nuclear factor kappa-B (NF-κB), thereby alleviating tissue inflammation caused by chronic ischemia, reducing muscle cell apoptosis, inhibiting M1 macrophage polarization, and promoting angiogenesis. : Our research suggests that BBM has the potential to protect against ischemic damage in lower limb muscle tissue, providing a new approach to the treatment of CLTI.
慢性肢体威胁性缺血（CLTI）是一种由血管病变引起的慢性肢体缺血性疾病，其特征为疼痛、溃疡和坏疽，严重时可危及生命。本研究的目的是探讨小檗胺（BBM）是否能保护和修复下肢缺血性肌肉组织；使用小鼠后肢缺血（HLI）模型，将36只C57BL6小鼠分为假手术组、HLI组和HLI+BBM治疗组。我们的研究结果表明，BBM可以恢复小鼠的运动功能和肌肉组织病理学，可能是通过抑制核因子κB（NF-κB）的核转位，从而减轻慢性缺血引起的组织炎症，减少肌肉细胞凋亡，抑制M1巨噬细胞极化，并促进血管生成。我们的研究表明，BBM有潜力保护下肢肌肉组织免受缺血损伤，为CLTI的治疗提供了一种新方法。
