Advanced (magnetic) Theranostic Nanostructures Group, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n 4715-330, Braga, Portugal.
Nanoscale. 2017 Aug 10;9(31):11318-11326. doi: 10.1039/c7nr01733b.
The complex and specialised diagnostic process through magnetic resonance imaging (MRI) could be simplified with the implementation of dual T-T contrast agents. T- and T-weighted MR are compatible modalities, and co-acquisition of contrast enhanced images in both T and T will drastically reduce artefacts and provide double-checked results. To date, efforts in the development of dual MRI probes have provided inconsistent results. Here we present the preparation and relaxometric study of a dual T-T MRI probe based on superparamagnetic nanoparticles, paramagnetic Gd chelates and pNIPAM (poly(N-isopropylacrylamide)), in which the distance between paramagnetic and superparamagnetic species can be modulated externally via temperature variations. Such a probe alleviates traditional nanotechnology limitations (e.g. batch to batch variability) as comparisons can be established within a single probe.
通过磁共振成像（MRI）进行复杂且专业的诊断过程可以通过实施双 T-T 对比剂来简化。T-和 T-加权磁共振是兼容的模态，同时采集 T 和 T 增强对比度图像将大大减少伪影并提供双重检查结果。迄今为止，双 MRI 探针的开发工作取得的结果并不一致。在这里，我们介绍了一种基于超顺磁纳米粒子、顺磁 Gd 螯合物和 pNIPAM（聚（N-异丙基丙烯酰胺））的双 T-T MRI 探针的制备和弛豫研究，其中通过温度变化可以调节顺磁和超顺磁物质之间的距离。这种探针缓解了传统纳米技术的局限性（例如批次间的可变性），因为可以在单个探针内建立比较。
