Valizadeh Majid, Nazeri Pantea, Fazli Farzaneh, Mohammadian Farnaz, Kalantari Sadreddin, Kamali Koorosh, Osali Hesam
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J Pediatr Endocrinol Metab. 2017 Aug 28;30(9):967-972. doi: 10.1515/jpem-2017-0087.
The aim of the present study was to investigate the effect of povidone-iodine (PVP-I) application at delivery on maternal urinary iodine concentration (UIC) and neonatal thyrotropin concentration.
In this cross-sectional study, urine samples were collected from each pregnant woman after admission to the hospital and before routine application of the PVP-I for delivery preparation and after delivery at time of screening for congenital hypothyroidism. A heel-prick blood sample was taken from all newborns.
A total of 394 pregnant women at time of delivery participated in this study. Median (interquartile range [IQR]) maternal UIC values were 120 (105-157) and 253 (126-470) μg/L before and after delivery, respectively (p<0.001). No significant correlations were observed between maternal UIC before and after delivery and neonatal thyrotropin levels.
Application of PVP-I significantly increased UIC in postpartum mothers; however, thyrotropin concentration in neonates, whose mothers had adequate UIC, was within the normal range.
本研究旨在探讨分娩时应用聚维酮碘（PVP-I）对产妇尿碘浓度（UIC）及新生儿促甲状腺激素浓度的影响。
在这项横断面研究中，收集每位孕妇入院后、分娩准备常规应用PVP-I之前以及分娩后先天性甲状腺功能减退筛查时的尿液样本。采集所有新生儿足跟血样本。
共有394名孕妇在分娩时参与了本研究。产妇分娩前和分娩后的UIC中位数（四分位数间距[IQR]）分别为120（105 - 157）μg/L和253（126 - 470）μg/L（p<0.001）。分娩前后产妇UIC与新生儿促甲状腺激素水平之间未观察到显著相关性。
应用PVP-I显著提高了产后母亲的UIC；然而，母亲UIC充足的新生儿促甲状腺激素浓度在正常范围内。
