Jacquot C, Barreteau H, Trouvin J H, Gayral P, Leroy J P
Life Sci. 1986 Oct 27;39(17):1539-42. doi: 10.1016/0024-3205(86)90384-x.
Some putative neurotransmitters in three experimental filariasis models were investigated by a new relevant chromatographic method, sensitive and specific. No catecholaminergic compounds have been detected, but serotonin was found in Dipetalonema vitae. However, further investigations revealed very high levels of gamma amino butyric acid (GABA) in the macro-filariae. These data allow us to foresee new fields in filariasis therapeutics.
采用一种新型相关色谱方法对三种实验性丝虫病模型中的一些假定神经递质进行了研究,该方法灵敏且特异。未检测到儿茶酚胺类化合物,但在犬恶丝虫中发现了血清素。然而,进一步研究发现,在成虫中γ-氨基丁酸(GABA)水平非常高。这些数据使我们能够预见丝虫病治疗的新领域。