Dehuri Priyadarshini, Gochhait Debasis, Srinivas B H, Sistla Sarath Chandra
Senior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Pondicherry, India.
Assistant Professor, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Pondicherry, India.
J Clin Diagn Res. 2017 Jun;11(6):ED01-ED03. doi: 10.7860/JCDR/2017/26738.9960. Epub 2017 Jun 1.
Paratesticular aggressive angiomyxoma is a very rare tumour in males. Most of documented cases of aggressive angiomyxomas have been seen in genital, perineal and pelvic regions in women of child bearing age. We report two cases of aggressive angiomyxomas in males who presented with inguinal swellings. A globular mass with greyish white, glistening cut surface was received after excision of the mass. Microscopic examination revealed a paucicellular tumour comprising of spindle shaped cells along with vessels of varying calibre. The accompanying stroma was myxocollagenous. In addition there was evidence of fat infiltration in one of the cases. Immunohistochemical staining showed CD34, desmin, vimetin positivity and negative staining for S100, actin, Estrogen Receptors (ER) and Progesterone Receptors (PR). The microscopic and immunohistochemical features favoured the diagnosis of aggressive angiomyxoma. This report of angiomyxoma in two cases of males assumes great significance in view of the extreme rarity of the tumour in males and its locally infiltrative nature.
睾丸旁侵袭性血管黏液瘤是男性极为罕见的肿瘤。大多数已记录的侵袭性血管黏液瘤病例见于育龄期女性的生殖器、会阴和盆腔区域。我们报告两例男性侵袭性血管黏液瘤病例，患者均表现为腹股沟肿胀。肿块切除后可见一个表面灰白色、有光泽的球形肿物。显微镜检查显示，肿瘤细胞稀少，由梭形细胞和不同管径的血管组成。伴随的间质为黏液胶原性。此外，其中一例有脂肪浸润的证据。免疫组化染色显示CD34、结蛋白、波形蛋白呈阳性，而S100、肌动蛋白、雌激素受体（ER）和孕激素受体（PR）呈阴性染色。显微镜和免疫组化特征支持侵袭性血管黏液瘤的诊断。鉴于该肿瘤在男性中极为罕见且具有局部浸润性，这两例男性血管黏液瘤的报告具有重要意义。
