Nayar Sushma, Parvathi Kishore Babu Esakkimuthu, Kaliannan Mayilananthi, Sivasailam Premlatha
Associate Professor, Department of Pathology, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Chennai, Tamil Nadu, India.
Assistant Professor, Department of Surgery, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Chennai, Tamil Nadu, India.
J Clin Diagn Res. 2017 Jun;11(6):ED21-ED23. doi: 10.7860/JCDR/2017/21598.10109. Epub 2017 Jun 1.
Acquired coagulation factor VIII inhibitor leads to a rare disease i.e., acquired haemophilia which is idiopathic in majority of cases and is seen with autoimmune diseases, haematologic and solid tumours, infections, in the post-partum period and also with certain long-term use of drugs like penicillin and its derivatives, phenytoin, sulfa antibiotics, chloramphenicol, methyldopa, chlorpromazine, levodopa, interferon-α, fludarabine, clopidogrel. We report a case here, with acquired Factor VIII (FVIII) inhibitor acquisition which presented with delayed wound healing as a result of protracted bleeding into the wound. The inhibitor was acquired due to prolonged chlorpromazine use.
获得性凝血因子 VIII 抑制剂可导致一种罕见疾病，即获得性血友病，该病在大多数情况下为特发性，可见于自身免疫性疾病、血液系统和实体肿瘤、感染、产后时期，以及长期使用某些药物如青霉素及其衍生物、苯妥英、磺胺类抗生素、氯霉素、甲基多巴、氯丙嗪、左旋多巴、干扰素-α、氟达拉滨、氯吡格雷的情况。我们在此报告一例因长期使用氯丙嗪而获得性出现凝血因子 VIII（FVIII）抑制剂的病例，该病例因伤口持续出血导致伤口愈合延迟。
