Pradeepkumar Bhupalam, Bhavyamadhuri C P, Padmanabhareddy Y, Veerabhadrappa K V, Narayana Gorantla, Haranath C, Somasekharreddy K, Sudheer Akkiraju
Associate Professor and Head, Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India.
Pharmacy Student, Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India.
J Clin Diagn Res. 2017 Jun;11(6):FF01-FF03. doi: 10.7860/JCDR/2017/26171.9998. Epub 2017 Jun 1.
is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity.
To evaluate the antiulcer activity of methanolic extract of the leaves of (MEPP) on albino rats.
The rats were divided into four groups as control, standard, test 1 (extract: 100 mg/kg) and test 2 (extract: 200 mg/kg) with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with MEPP at doses of 100 and 200 mg/kg. To determine the antiulcer activity of extract, mean ulcer index, free acidity and total acidity were evaluated.
Ulcer index was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Total and free acidity was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Histological analysis also supported the gastro protective effect of MEPP treated groups when compared with control groups.
The study revealed that MEPP exhibited potential antiulcer activity and showed dose dependent antiulcer effect.
是酚类物质的丰富来源，该植物的木材、叶子和花朵在传统医学中用作药物。消化性溃疡是胃肠道的一种主要疾病，全球每年影响近400万人，不同病因影响世界10%的人口。含有具有潜在抗氧化和细胞保护活性的酚类、黄酮类和单宁。
评估[植物名称]叶甲醇提取物（MEPP）对白化大鼠的抗溃疡活性。
将大鼠分为四组，即对照组、标准组、试验1组（提取物：100mg/kg）和试验2组（提取物：200mg/kg），每组6只大鼠。通过口服吲哚美辛（20mg/kg）然后进行幽门结扎诱导胃损伤。标准组动物用米索前列醇治疗，试验组动物用100和200mg/kg剂量的MEPP治疗。为了确定提取物的抗溃疡活性，评估了平均溃疡指数、游离酸度和总酸度。
与对照组相比，MEPP治疗组的溃疡指数在p<0.01时显著降低。与对照组相比，MEPP治疗组的总酸度和游离酸度在p<0.01时显著降低。组织学分析也支持MEPP治疗组与对照组相比的胃保护作用。
该研究表明MEPP具有潜在的抗溃疡活性，并显示出剂量依赖性抗溃疡作用。
