Shugalev N P
Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 Jul-Aug;36(4):652-9.
Pharmacological action on cholinergic and monoaminergic brain structures in the process of food-procuring reflex extinction was studied in intact and lobectomized cats. Growing stimulation of cholinergic structures of lobectomized animals caused consecutive behavioural changes similar to those appearing during development of active reaction of intact animals to cancellation of the reflex reinforcement. In both cases influences on monoaminergic systems produced analogous effects, but suppressing influence of haloperidol injection on food-procuring activity of lobectomized cats was significantly weakened. Conclusion is made that the development of active reaction of the animal to cancellation of food reinforcement is due to an increasing activation of brain cholinergic structures and consecutive activation of monoaminergic structures. Disturbance of extinction functions in lobectomized cats may be connected with disturbance of monoaminergic systems balance as a result of hyperactivity of dopaminergic structures.
在完整和切除脑叶的猫身上，研究了食物获取反射消退过程中对胆碱能和单胺能脑结构的药理作用。对切除脑叶动物的胆碱能结构的逐渐刺激导致了连续的行为变化，类似于完整动物对反射强化取消的主动反应发展过程中出现的变化。在这两种情况下，对单胺能系统的影响产生了类似的效果，但氟哌啶醇注射对切除脑叶猫的食物获取活动的抑制作用明显减弱。得出的结论是，动物对食物强化取消的主动反应的发展是由于脑胆碱能结构的激活增加以及单胺能结构的连续激活。切除脑叶的猫的消退功能障碍可能与多巴胺能结构的过度活跃导致的单胺能系统平衡紊乱有关。
