Brandstetter G, Hoffmann H, Maderbacher H, Eslaminejad S
Acta Med Austriaca. 1986;13(2):29-37.
The influence of a once daily dose of 200 mg celiprolol alone and in combination with 12.5 mg chlorthalidone on uric acid and electrolyte metabolism was investigated in 22 hypertensive patients with gout in a randomized trial. All patients were treated with allopurinol and diet. A four weeks treatment with celiprolol (11 patients) showed no influence on uric acid metabolism, electrolytes, blood glucose, cholesterol and triglycerides. Under treatment with celiprolol plus chlorthalidone (11 patients) only a small rise in serum uric acid was observed after four weeks but at the same time uric acid clearance and excretion increased significantly. There was no obvious change in serum electrolytes but an increase in sodium, potassium and chloride urine excretion. Serum uric acid, uric acid clearance and excretion decreased during a 6 months treatment period. A small decrease in cholesterol and triglycerides was observed. Blood pressure decreased in both treatment groups but there was only a small change in heart rate.
在一项随机试验中，对22例痛风高血压患者研究了每日一次单独服用200毫克塞利洛尔以及与12.5毫克氯噻酮联合使用对尿酸和电解质代谢的影响。所有患者均接受别嘌呤醇治疗并控制饮食。对11例患者进行为期四周的塞利洛尔治疗，结果显示对尿酸代谢、电解质、血糖、胆固醇和甘油三酯均无影响。在11例患者接受塞利洛尔加氯噻酮治疗后，四周后仅观察到血清尿酸略有升高，但同时尿酸清除率和排泄量显著增加。血清电解质无明显变化，但尿钠、钾和氯排泄量增加。在6个月的治疗期内，血清尿酸、尿酸清除率和排泄量下降。胆固醇和甘油三酯略有下降。两个治疗组的血压均下降，但心率仅有微小变化。
