Flexible imidazolium macrocycles: building blocks for anion-induced self-assembly.

This feature article summarises recent contributions of the authors in the area of anion-induced supramolecular self-assembly. It is based on the chemistry of a set of tetracationic imidazolium macrocycles, specifically the so-called 'Texas-sized' molecular box, cyclo22 (1), and its congeners, cyclo22 (2), cyclo22 (3), and cyclo22 (4). These systems collectively have been demonstrated as being versatile building blocks that interact with organic carboxylate or sulfonate anions, as well as substrates (e.g., neutral molecules or metal cations). Most work to date has been carried out with 1, a system that has been found to support the construction of a number of stimuli responsive self-assembled ensembles. This macrocycle and others of the 'Texas-sized' box family also show the potential to react as carbene precursors and to undergo post-synthetic modification (PSM) to produce new functional macrocycles, such as trans- and cis-cyclo22 (5 and 6, respectively). On the basis of the work reviewed in this Feature article, we propose that the imidazolium macrocycles 1-4 can be considered as useful tools for the construction of ensembles with environmentally responsive features, including control over self-assembly and an ability to undergo precursor-specific PSM.