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Mid-Treatment Sleep Duration Predicts Clinically Significant Knee Osteoarthritis Pain reduction at 6 months: Effects From a Behavioral Sleep Medicine Clinical Trial.治疗中期的睡眠时间可预测6个月时临床上显著的膝关节骨关节炎疼痛减轻:一项行为睡眠医学临床试验的结果
Sleep. 2017 Feb 1;40(2). doi: 10.1093/sleep/zsw064.
2
Recent developments in emerging therapeutic targets of osteoarthritis.骨关节炎新兴治疗靶点的最新进展。
Curr Opin Rheumatol. 2017 Jan;29(1):96-102. doi: 10.1097/BOR.0000000000000351.
3
Determinants of pain and functioning in knee osteoarthritis: a one-year prospective study.膝关节骨关节炎疼痛及功能的决定因素:一项为期一年的前瞻性研究。
Clin Rehabil. 2016 Sep;30(9):890-900. doi: 10.1177/0269215515619660.
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Examining the Relationship Between Worry and Sleep: A Daily Process Approach.探究担忧与睡眠之间的关系:一种日常过程研究方法。
Behav Ther. 2016 Jul;47(4):460-73. doi: 10.1016/j.beth.2015.12.003. Epub 2015 Dec 29.
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Preoperative pain catastrophizing and postoperative pain after total knee arthroplasty: a prospective cohort study with one year follow-up.全膝关节置换术后术前疼痛灾难化与术后疼痛:一项为期一年随访的前瞻性队列研究
BMC Musculoskelet Disord. 2016 May 17;17:214. doi: 10.1186/s12891-016-1073-0.
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Gender Differences in Patients with Fibromyalgia Undergoing Cognitive-Behavioral Therapy for Insomnia: Preliminary Data.纤维肌痛患者接受失眠认知行为疗法时的性别差异:初步数据。
Pain Pract. 2016 Feb;16(2):E23-34. doi: 10.1111/papr.12411.
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Prevalence of Total Hip and Knee Replacement in the United States.美国全髋关节和膝关节置换的患病率。
J Bone Joint Surg Am. 2015 Sep 2;97(17):1386-97. doi: 10.2106/JBJS.N.01141.
8
Sleep, Pain Catastrophizing, and Central Sensitization in Knee Osteoarthritis Patients With and Without Insomnia.伴有和不伴有失眠的膝骨关节炎患者的睡眠、疼痛灾难化思维与中枢敏化
Arthritis Care Res (Hoboken). 2015 Oct;67(10):1387-96. doi: 10.1002/acr.22609.
9
Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis.睡眠中断与膝关节骨关节炎中按性别和种族划分的疼痛处理改变有关。
J Pain. 2015 May;16(5):478-90. doi: 10.1016/j.jpain.2015.02.004. Epub 2015 Feb 25.
10
Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review.疼痛灾难化作为全膝关节置换术后慢性疼痛的危险因素:一项系统综述
J Pain Res. 2015 Jan 5;8:21-32. doi: 10.2147/JPR.S64730. eCollection 2015.

针对睡眠的心理干预可减少膝骨关节炎的疼痛灾难化。

Psychological interventions that target sleep reduce pain catastrophizing in knee osteoarthritis.

机构信息

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Pain. 2017 Nov;158(11):2189-2195. doi: 10.1097/j.pain.0000000000001023.

DOI:10.1097/j.pain.0000000000001023
PMID:28767510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5640483/
Abstract

Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait through the pain catastrophizing scale and measured as a daytime and nocturnal state through daily diaries. Secondary analyses were conducted on data collected as part of a randomized controlled trial assessing the effectiveness of cognitive behavioral therapy for insomnia in patients with KOA at 5 different time points: pretreatment, midtreatment and posttreatment and at 3- and 6-month follow-up. One hundred patients diagnosed with KOA and insomnia were randomized to receive either 8 sessions of cognitive behavioral therapy for insomnia or a placebo intervention of behavioral desensitization. Multilevel modeling revealed that both intervention groups showed a significant reduction pretreatment to posttreatment in all 3 measures of pain catastrophizing and maintained stable levels through the 6-month follow-up. Increased sleep continuity early in treatment (pretreatment to midtreatment), but not reductions in pain, was associated with a reduction in trait and nocturnal catastrophizing later in treatment (midtreatment to posttreatment). These results suggest that short interventions focusing on sleep can significantly reduce pain catastrophizing even in a clinical population with low baseline levels of catastrophizing, possibly through improving sleep continuity.

摘要

疼痛灾难化是膝骨关节炎(KOA)患者的一个重要风险因素,因此是许多针对疼痛的心理干预的目标。本研究考察了针对睡眠的干预措施是否能有效改善 KOA 患者的睡眠,同时通过疼痛灾难化量表衡量特质,通过日常日记衡量白天和夜间状态,从而降低疼痛灾难化。这是一项对随机对照试验数据进行的二次分析,评估认知行为疗法对 KOA 患者失眠的有效性,该试验在 5 个不同时间点收集数据:治疗前、治疗中、治疗后以及 3 个月和 6 个月随访。100 名被诊断为 KOA 和失眠的患者被随机分配接受 8 节认知行为疗法治疗失眠或行为脱敏的安慰剂干预。多层次模型显示,两个干预组在所有 3 项疼痛灾难化测量中均显示出治疗前至治疗后的显著降低,并在 6 个月的随访中保持稳定水平。治疗早期(治疗前至治疗中)的睡眠连续性增加,但疼痛减轻与治疗后期(治疗中至治疗后)特质和夜间灾难化的降低有关。这些结果表明,即使在基线灾难化水平较低的临床人群中,专注于睡眠的短期干预也可以显著降低疼痛灾难化,可能是通过改善睡眠连续性实现的。