多发性硬化症的补充和替代治疗：2001 年至 2016 年证据综述。

Complementary and alternative treatments of multiple sclerosis: a review of the evidence from 2001 to 2016.

机构信息

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

出版信息

J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):34-41. doi: 10.1136/jnnp-2016-314490. Epub 2017 Aug 2.

DOI:10.1136/jnnp-2016-314490

Abstract

People with multiple sclerosis (PwMS) commonly use complementary and alternative medicines (CAM), but an understanding of their efficacy is lacking. Here, we quantitatively review the class I and class II studies of treatment efficacy for multiple sclerosis from January 2001 to January 2017, in order to assess the modern evidence for CAM use. The 38 studies included in this review are divided across five CAM types (cannabis, diet, exercise, psychological approaches and other). We found little evidence to support CAM efficacy. The studies contained little replication in intervention, primary outcomes or study design. Six of 16 CAMs included in this review were only researched in a single study. Future work in this area should build consensus around study methodologies and primary outcomes.

摘要

多发性硬化症（MS）患者通常会使用补充和替代医学（CAM），但对其疗效的了解还很缺乏。在这里，我们定量回顾了 2001 年 1 月至 2017 年 1 月间的 I 类和 II 类多发性硬化症治疗疗效的研究，以评估 CAM 使用的现代证据。本综述中包括的 38 项研究分为五类 CAM 类型（大麻、饮食、运动、心理方法和其他）。我们发现几乎没有证据支持 CAM 的疗效。这些研究在干预、主要结果或研究设计方面几乎没有重复。本综述中包括的 16 种 CAM 中有 6 种仅在一项研究中进行了研究。该领域的未来工作应围绕研究方法和主要结果达成共识。