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一名老年男性慢性硬膜下血肿后出现孤立性促肾上腺皮质激素缺乏:存在关联吗?

Isolated Adrenocorticotropic Hormone Deficiency Following Chronic Subdural Hematoma in an Elderly Man: Is There a Connection?

作者信息

Suzuki Satoshi, Suzuki Keiko

机构信息

Department of General Internal Medicine, Asahikawa City Hospital, Japan.

出版信息

Intern Med. 2017;56(15):1981-1985. doi: 10.2169/internalmedicine.56.6792. Epub 2017 Aug 1.

DOI:10.2169/internalmedicine.56.6792
PMID:28768968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5577074/
Abstract

The delayed diagnosis of adrenal insufficiency is relatively common because its symptoms are non-specific. One of the causes of adrenal insufficiency is isolated adrenocorticotropic hormone deficiency (IAD), which is sometimes caused by traumatic brain injury. Indeed, severe head trauma is considered to contribute to the incidence of this disease. However, the relationship between milder head trauma-such as chronic subdural hematoma - and the occurrence of hormonal deficiency is uncertain. We herein report the case of a 79-year-old man with IAD who presented with leg edema and pain in his extremities following a recent history of chronic subdural hematoma.

摘要

肾上腺功能不全的延迟诊断相对常见,因为其症状不具有特异性。肾上腺功能不全的病因之一是孤立性促肾上腺皮质激素缺乏症(IAD),其有时由创伤性脑损伤引起。确实,严重头部创伤被认为会导致这种疾病的发生。然而,较轻的头部创伤(如慢性硬膜下血肿)与激素缺乏症的发生之间的关系尚不确定。我们在此报告一例79岁患有IAD的男性病例,该患者在近期有慢性硬膜下血肿病史后出现腿部水肿和四肢疼痛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f65/5577074/cdc34b628c00/1349-7235-56-1981-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f65/5577074/676adbe30804/1349-7235-56-1981-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f65/5577074/cdc34b628c00/1349-7235-56-1981-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f65/5577074/676adbe30804/1349-7235-56-1981-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f65/5577074/cdc34b628c00/1349-7235-56-1981-g002.jpg

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本文引用的文献

1
Hypopituitarism after traumatic brain injury.创伤性脑损伤后的垂体功能减退
Endocrinol Metab Clin North Am. 2015 Mar;44(1):151-9. doi: 10.1016/j.ecl.2014.10.012. Epub 2014 Nov 4.
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Adrenal insufficiency.肾上腺功能不全。
Lancet. 2014 Jun 21;383(9935):2152-67. doi: 10.1016/S0140-6736(13)61684-0. Epub 2014 Feb 4.
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Painful hypoadrenalism.疼痛性肾上腺皮质功能减退症
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Hypothalamo-pituitary dysfunction in patients with chronic subdural hematoma.慢性硬脑膜下血肿患者的下丘脑-垂体功能障碍。
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Improved response of growth hormone to growth hormone-releasing hormone and reversible chronic thyroiditis after hydrocortisone replacement in isolated adrenocorticotropic hormone deficiency.在孤立性促肾上腺皮质激素缺乏症中,氢化可的松替代治疗后生长激素对生长激素释放激素的反应改善及可逆性慢性甲状腺炎。
Tokai J Exp Clin Med. 2009 Jul 20;34(2):34-8.
6
Musculoskeletal symptoms and neurological investigations in adrenocortical insufficiency: a case report and literature review.肾上腺皮质功能不全的肌肉骨骼症状及神经学检查:一例报告及文献综述
J Musculoskelet Neuronal Interact. 2010 Dec;10(4):281-5.
7
Delayed diagnosis of adrenal insufficiency is common: a cross-sectional study in 216 patients.肾上腺功能不全的延迟诊断很常见:216 例患者的横断面研究。
Am J Med Sci. 2010 Jun;339(6):525-31. doi: 10.1097/MAJ.0b013e3181db6b7a.
8
Prevalence of maturity-onset isolated ACTH deficiency (IAD) in 2005: Japanese cohort studies.2005年成人起病型孤立性促肾上腺皮质激素缺乏症(IAD)的患病率:日本队列研究
Endocr J. 2008 Oct;55(5):939-41. doi: 10.1507/endocrj.k08e-146. Epub 2008 Jun 14.
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Secondary hypoadrenalism.继发性肾上腺功能减退症
Pituitary. 2008;11(2):147-54. doi: 10.1007/s11102-008-0108-4.
10
Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review.创伤性脑损伤和动脉瘤性蛛网膜下腔出血后的下丘脑垂体功能障碍:一项系统评价
JAMA. 2007 Sep 26;298(12):1429-38. doi: 10.1001/jama.298.12.1429.