Gikavyĭ V I, Ershova I N, Mukhin E A
Farmakol Toksikol. 1986 Sep-Oct;49(5):76-80.
Isoturone (5 mg/kg) administered in a single dose intravenously to unanesthetized cats in a torpid phase of traumatic shock increases arterial blood pressure (BP) and total peripheral vascular resistance (TPVR). The drug restores BP level mainly due to an increase of TPVR against background of neurovegetative blockade induced by pentamine, phentolamine and combinations of phentolamine with hexonium in the presence of a severe trauma. Vascular sensitivity to isoturone in traumatic shock is preserved and considerably increases during the use of the vasopressor in different types of neurovegetative blockade.
在创伤性休克的迟钝期，以单剂量静脉注射给予未麻醉的猫5毫克/千克的异托龙，可提高动脉血压（BP）和总外周血管阻力（TPVR）。在严重创伤存在的情况下，在五胺、酚妥拉明以及酚妥拉明与己铵的组合所诱导的神经植物性阻滞背景下，该药物主要通过增加TPVR来恢复血压水平。在不同类型的神经植物性阻滞中使用血管升压药时，创伤性休克中血管对异托龙的敏感性得以保留并显著增加。
