恶性肿瘤中与博来霉素治疗相关的肺部病变

PULMONARY LESIONS ASSOCIATED WITH BLEOMYCIN THERAPY IN MALIGNANCIES.

作者信息

Bhardwaj J R, Kartik K, Sambandam S

机构信息

Professor & Head, Pune-411 040.

PG Student; Department of Pathology, Armed Forces Medical College, Pune-411 040.

出版信息

Med J Armed Forces India. 1994 Jul;50(3):167-170. doi: 10.1016/S0377-1237(17)31052-3. Epub 2017 Jun 27.

DOI:10.1016/S0377-1237(17)31052-3

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5529761/

Abstract

Pulmonary lesions in seven patients with malignancy who were treated with bleomycin were studied at autopsy. Six of them had symptoms of respiratory distress. The lesions showed a predilection for the lower lobe and subpleural zones. Diffuse alveolar damage progressing to interstitial pneumonitis at varying stages of evolution was observed in all cases. The changes included intra-alveolar proteinaceous exudate, extensive interstitial fibrosis and frank epithelial dysplasia simulating metastatic nodules.

摘要

对7例接受博来霉素治疗的恶性肿瘤患者的肺部病变进行了尸检研究。其中6例有呼吸窘迫症状。病变好发于下叶和胸膜下区域。所有病例均观察到弥漫性肺泡损伤在不同演变阶段进展为间质性肺炎。这些变化包括肺泡内蛋白质渗出物、广泛的间质纤维化以及类似转移结节的明显上皮发育异常。

相似文献

1

PULMONARY LESIONS ASSOCIATED WITH BLEOMYCIN THERAPY IN MALIGNANCIES.

Med J Armed Forces India. 1994 Jul;50(3):167-170. doi: 10.1016/S0377-1237(17)31052-3. Epub 2017 Jun 27.

2

Two forms of diffuse alveolar damage in the lungs of patients with acute respiratory distress syndrome.

Hum Pathol. 2009 Nov;40(11):1618-27. doi: 10.1016/j.humpath.2009.04.019. Epub 2009 Aug 3.

3

Fatal interstitial pneumonitis induced by low dosage of bleomycin in an esophageal cancer patient.

Jpn J Surg. 1979 Dec;9(4):366-71. doi: 10.1007/BF02468638.

4

[Bleomycin lung (author's transl)].

Dtsch Med Wochenschr. 1977 Feb 25;102(8):281-9. doi: 10.1055/s-0028-1104879.

5

Pathology of hypersensitivity pneumonitis.

Curr Opin Pulm Med. 2008 Sep;14(5):440-54. doi: 10.1097/MCP.0b013e3283043dfa.

6

Pulmonary pathology of the adult respiratory distress syndrome.

Clin Chest Med. 1990 Dec;11(4):593-619.

7

Bleomycin lung damage: the pathology and nature of the lesion.

Br J Dis Chest. 1978 Oct;72(4):321-6.

8

[DNA strand breaks in epithelial cells from mice with bleomycin induced pulmonary fibrosis].

Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Jan;34(1):3-8.

9

[Pulmonary epithelial permeability in rats with bleomycin-induced pneumonitis].

Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Jul;30(7):1222-8.

10

Pulmonary responses to bleomycin-induced injury: an immunomorphologic and electron microscopic study.

Exp Pathol. 1985;28(1):33-43. doi: 10.1016/s0232-1513(85)80030-x.

本文引用的文献

1

Early diagnosis of bleomycin pulmonary toxicity using bronchoalveolar lavage in dogs.

Am Rev Respir Dis. 1982 Jul;126(1):126-30. doi: 10.1164/arrd.1982.126.1.126.

2

Bleomycin toxicity simulating metastatic nodules to the lungs.

Cancer. 1981 Sep 1;48(5):1096-100. doi: 10.1002/1097-0142(19810901)48:5<1096::aid-cncr2820480508>3.0.co;2-y.

3

Study of the clinical efficiency of bleomycin in human cancer.

Br Med J. 1970 Jun 13;2(5710):643-5.

4

Studies on bleomycin.

Cancer. 1967 May;20(5):891-5. doi: 10.1002/1097-0142(1967)20:5<891::aid-cncr2820200550>3.0.co;2-v.

5

[Pulmonary lesions produced by antitumor drugs--studies on autopsy cases].

Gan No Rinsho. 1971;17(1):21-34.

6

The pulmonary changes of bleomycin toxicity.

Radiology. 1973 Jan;106(1):65-8. doi: 10.1148/106.1.65.

7

Interstitial pneumonitis associated with bleomycin therapy.

Am J Clin Pathol. 1972 Nov;58(5):501-10. doi: 10.1093/ajcp/58.5.501.

8

Drug-related pulmonary toxicity in non-Hodgkin's lymphoma. Comparative results with three different treatment regimens.

Cancer. 1991 Aug 15;68(4):699-705. doi: 10.1002/1097-0142(19910815)68:4<699::aid-cncr2820680406>3.0.co;2-5.

9

Immunosuppressive and cytotoxic chemotherapy: long-term complications.

Ann Intern Med. 1975 Jan;82(1):84-95. doi: 10.7326/0003-4819-82-1-84.

10

Combination chemotherapy of advanced non-Hodgkin lymphoma with bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP).

Blood. 1977 May;49(5):759-70.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。