Jones A W
Br J Dis Chest. 1978 Oct;72(4):321-6.
The pathology of two cases of pulmonary damage due to bleomycin is described. The drug damages the alveolar walls. A sequence of pathological changes could be traced commencing with oedema, intra-alveolar fibrin and haemorrhage, followed by type II pneumocyte hyperplasia associated with bronchial epithelial squamous metaplasia. This led to intra-alveolar and alveolar wall collagen formation producing diffuse interstitial fibrosis with microcyst formation associated with cuboidalization of the epithelium. These changes are similar to those seen in experimental bleomycin damage in mice, where it has been shown that the changes are the result of vascular damage and type I pneumocyte necrosis. It is inferred that human diffuse alveolar damage develops in the same way.
描述了两例因博来霉素导致肺损伤的病理情况。该药物损害肺泡壁。可以追溯到一系列病理变化，始于水肿、肺泡内纤维蛋白和出血，随后是与支气管上皮鳞状化生相关的II型肺细胞增生。这导致肺泡内和肺泡壁胶原形成，产生弥漫性间质纤维化并伴有微囊肿形成，同时伴有上皮立方化。这些变化与在小鼠实验性博来霉素损伤中所见的变化相似，在小鼠实验中已表明这些变化是血管损伤和I型肺细胞坏死的结果。据推测，人类弥漫性肺泡损伤也是以同样的方式发展的。
