Bhardwaj J R, Somanathan T, Kumar Harsh, Sivadas P, Reddy P S
Senior Adviser (Pathology), Army Hospital, Delhi Cantt.
Post Graduate, Dept of Pathology, Armed Forces Medical College, Pune.
Med J Armed Forces India. 1996 Jan;52(1):27-31. doi: 10.1016/S0377-1237(17)30830-4. Epub 2017 Jun 26.
Twenty pituitary adenomas were studied using light microscopy, immunohistochemistry and electron microscopy. Based on clinical manifestations of hormonal hypersecretion they were divided into two groups, i.e. group-I (12 patients) with no endocrine dysfunction and group-II (8 patients) with endocrine dysfunction. Group-I could be further sub-divided into two groups based on IHC : group LA in which no hormone could be localised in the tissue (null cell adenomas) and group IB where hormones could be localised in the tissue (1). Tumours in group II, with light microscopy, were acidophil (n=5), basophil (n=1) or mixed (n=2) adenomas. Eight of these 20 cases were plurihormonal. Growth hormone, and prolactin were the commonest combination. This study has helped in the reclassification of the pituitary adenomas according to the hormone they produce.
采用光学显微镜、免疫组织化学和电子显微镜对20例垂体腺瘤进行了研究。根据激素分泌过多的临床表现，将它们分为两组，即无内分泌功能障碍的I组（12例患者）和有内分泌功能障碍的II组（8例患者）。I组根据免疫组织化学可进一步细分为两组：LA组，组织中未发现激素（无功能性腺瘤）；IB组，组织中可发现激素（1例）。II组肿瘤，光学显微镜下观察，为嗜酸细胞瘤（n = 5）、嗜碱细胞瘤（n = 1）或混合性腺瘤（n = 2）。这20例中有8例为多激素型。生长激素和催乳素是最常见的组合。这项研究有助于根据垂体腺瘤所产生的激素对其进行重新分类。
