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COMPLEMENT MEDIATED LYSIS, ADHESION, INVASION, AND MULTIPLICATION WITHIN HeLa CELLS AND HUMAN MONOCYTE MACROPHAGES OF SUSCEPTIBLE AND MULTIPLE DRUG-RESISTANT .补体介导的在HeLa细胞以及敏感和多重耐药的人类单核巨噬细胞内的溶解、黏附、侵袭及增殖
Med J Armed Forces India. 1996 Jul;52(3):161-165. doi: 10.1016/S0377-1237(17)30792-X. Epub 2017 Jun 26.
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本文引用的文献

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Correlation between the presence of a fifty-megadalton plasmid in Salmonella dublin and virulence for mice.都柏林沙门氏菌中五十兆道尔顿质粒的存在与对小鼠的毒力之间的相关性。
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Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication.猪霍乱沙门氏菌、福氏志贺氏菌和小肠结肠炎耶尔森氏菌侵入培养的动物细胞所采用的侵袭策略比较：细菌侵袭或细胞内复制不需要内体酸化。
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Sequence analysis of rsk, a portion of the 95-kilobase plasmid of Salmonella typhimurium associated with resistance to the bactericidal activity of serum.鼠伤寒沙门氏菌95千碱基质粒中与血清杀菌活性抗性相关的rsk部分的序列分析。
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补体介导的在HeLa细胞以及敏感和多重耐药的人类单核巨噬细胞内的溶解、黏附、侵袭及增殖

COMPLEMENT MEDIATED LYSIS, ADHESION, INVASION, AND MULTIPLICATION WITHIN HeLa CELLS AND HUMAN MONOCYTE MACROPHAGES OF SUSCEPTIBLE AND MULTIPLE DRUG-RESISTANT .

作者信息

Menon P Krishna

机构信息

Classified Specialist (Pathology), 7 Air Force Hospital, Nathu Singh Road, Kanpur 208004.

出版信息

Med J Armed Forces India. 1996 Jul;52(3):161-165. doi: 10.1016/S0377-1237(17)30792-X. Epub 2017 Jun 26.

DOI:10.1016/S0377-1237(17)30792-X
PMID:28769376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5530399/
Abstract

Twenty strains each of susceptible and multiple drug resistant strains of were compared for susceptibility to complement lysis and cellular invasion. Drug resistant strains showed increased resistance to complement killing. Antibody increased the efficiency of complement killing of Susceptible and drug resistant strains showed almost the same rates of adherence and invasion of HeLa cells and human monocyte cell lines. However, the resistant strains showed a relatively higher rate of intracellular multiplication after 6 hours within human mononuclear macrophages. Decreased killing by complement and the relatively higher multiplication within mononuclear macrophages of the drug resistant strains may be the reason for their increased virulence.

摘要

对20株敏感菌株和20株多重耐药菌株进行了补体裂解敏感性和细胞侵袭能力的比较。耐药菌株对补体杀伤的抗性增强。抗体提高了补体对敏感菌株和耐药菌株的杀伤效率。敏感菌株和耐药菌株对HeLa细胞和人单核细胞系的黏附率和侵袭率几乎相同。然而，耐药菌株在人单核巨噬细胞内6小时后的细胞内增殖率相对较高。补体杀伤作用降低以及耐药菌株在单核巨噬细胞内相对较高的增殖率可能是其毒力增加的原因。