Zhao Juanjuan, Yue Dongxu, Zhou Ya, Jia Li, Wang Hairong, Guo Mengmeng, Xu Hualin, Chen Chao, Zhang Jidong, Xu Lin
Department of Immunology, Zunyi Medical College, Guizhou, China.
Department of Medical Physics, Zunyi Medical College, Guizhou, China.
Front Neurol. 2017 Jul 18;8:342. doi: 10.3389/fneur.2017.00342. eCollection 2017.
Alzheimer's disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system. Recent evidence showed that microRNAs (miRNAs) played important roles in the pathological progression of AD. In this article, we reviewed the promising role of miRNAs in both Aβ deposition and Tau phosphorylation, two key pathological characters in the pathological progression of AD, which might be helpful for the understanding of pathogenesis and the development of new strategies of clinical diagnosis and treatment of AD.
阿尔茨海默病（AD）是中枢神经系统最常见的退行性疾病，其主要临床特征为认知和行为功能进行性受损。最近的证据表明，微小RNA（miRNA）在AD的病理进展中发挥重要作用。在本文中，我们综述了miRNA在Aβ沉积和Tau磷酸化这两个AD病理进展中的关键病理特征方面的潜在作用，这可能有助于理解AD的发病机制以及开发新的临床诊断和治疗策略。
