Seo Hyun Il, Choi Kyoo-Ho, Han Koon Hee, Lee Sang Jin, Park Jong Kyu, Kim Young Don, Cheon Gab Jin
University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Republic of Korea.
Gastroenterol Res Pract. 2017;2017:1049810. doi: 10.1155/2017/1049810. Epub 2017 Jul 9.
While several case reports on ischemic colitis (IC) suggest the presence of predisposing causative factors, a few studies have investigated the predisposing factors in IC. This study aimed to identify the characteristics of patients with IC, particularly focusing on the predisposing factors.
We conducted a single-center, retrospective analysis of 159 patients with IC. Clinical characteristics, laboratory data, endoscopic findings, and medical records were reviewed. Data were compared between groups of patients defined according to the predisposing factors. The predisposing factors are defined as temporary states or episodic events occurring within a week before the development of IC such as colonoscopy, enema, use of laxatives, heavy drinking, pancreatitis, shock, and burn.
Compared to the group of patients without predisposing factors of IC, the group of patients with predisposing factors was characterized by a relatively higher prevalence of male sex (56.9% versus 33.3%, = 0.005), younger age (60.9 ± 15.4 versus 67.2 ± 13.4 years, = 0.010), lower incidence of hypertension (43.1% versus 60.2%, = 0.044), and fewer risk factors (1.24 ± 1.18 versus 1.82 ± 1.22, = 0.005).
Among men with predisposing factors, IC may develop even at a relatively younger age and in the absence of multiple risk factors, suggesting that predisposing factors may be involved in the pathogenesis of IC.
虽然几例缺血性结肠炎（IC）的病例报告提示存在诱发因素，但很少有研究对IC的诱发因素进行调查。本研究旨在确定IC患者的特征，尤其关注诱发因素。
我们对159例IC患者进行了单中心回顾性分析。回顾了临床特征、实验室数据、内镜检查结果及病历。对根据诱发因素定义的患者组之间的数据进行了比较。诱发因素定义为IC发病前一周内出现的临时状态或偶发事件，如结肠镜检查、灌肠、使用泻药、大量饮酒、胰腺炎、休克和烧伤。
与无IC诱发因素的患者组相比，有诱发因素的患者组具有男性患病率相对较高（56.9%对33.3%，P = 0.005）、年龄较轻（60.9±15.4岁对67.2±13.4岁，P = 0.010）、高血压发病率较低（43.1%对60.2%，P = 0.044）以及危险因素较少（1.24±1.18对1.82±1.22，P = 0.005）的特点。
在有诱发因素的男性中，即使相对年轻且无多种危险因素也可能发生IC，提示诱发因素可能参与了IC的发病机制。
