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迟发性囊袋阻滞综合征的手术治疗结果

Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome.

作者信息

Huang Yang, Ye Zi, Li Hang, Li Zhaohui

机构信息

Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China.

Medical Department, The First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China.

出版信息

J Ophthalmol. 2017;2017:1847179. doi: 10.1155/2017/1847179. Epub 2017 Jul 9.

DOI:10.1155/2017/1847179
PMID:28770106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5523514/
Abstract

PURPOSE

To further investigate the pathogenesis of late-onset capsular block syndrome (CBS) and to evaluate the safety of surgical treatment.

METHODS

Seven patients diagnosed with late-onset CBS were retrospectively analyzed. Anterior chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and best-corrected visual acuity (BCVA) before and after surgery were recorded. The opaque substance was tested with Western blot, and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor, respectively.

RESULTS

Patients who had undergone surgical treatment showed a significant BCVA and spherical equivalent refractive error improvement ( = 0.002, = 0.021, resp.). Nevertheless, ACD and IOP before and after surgery were in normal range with no difference ( = 0.165, = 0.749, resp.). B-crystallin and B-crystallin were detected in all opaque substances. Tumor necrosis factor-alpha (TNF-) and interlukin-1 (IL-1) levels in opaque substance were significantly higher than those in aqueous humor ( = 0.038, = 0.007, resp.), while IL-2 and IL-6 were not detected in any samples.

CONCLUSIONS

Opaque substance is derived from human lens epithelial cells. Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS. In addition, surgical treatment is an effective approach. This trial is registered with ChiCTR-IOR-17011287.

摘要

目的

进一步探讨迟发性晶状体后囊膜阻滞综合征（CBS）的发病机制，并评估手术治疗的安全性。

方法

对7例诊断为迟发性CBS的患者进行回顾性分析。记录手术前后的前房深度（ACD）、眼压（IOP）、屈光度数和最佳矫正视力（BCVA）。采用蛋白质免疫印迹法检测不透明物质，并利用流式细胞仪多阵列分析系统分别评估不透明物质和房水中炎性细胞因子的水平。

结果

接受手术治疗的患者BCVA和等效球镜屈光不正有显著改善（分别为P = 0.002，P = 0.021）。然而，手术前后的ACD和IOP均在正常范围内，无差异（分别为P = 0.165，P = 0.749）。在所有不透明物质中均检测到β-晶状体蛋白和γ-晶状体蛋白。不透明物质中肿瘤坏死因子-α（TNF-α）和白细胞介素-1（IL-1）水平显著高于房水（分别为P = 0.038，P = 0.007），而在任何样本中均未检测到IL-2和IL-6。

结论

不透明物质来源于人晶状体上皮细胞。炎性细胞因子可能参与迟发性CBS的发病机制。此外，手术治疗是一种有效的方法。本试验已在中国临床试验注册中心注册，注册号为ChiCTR-IOR-17011287。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/4730fdf536d9/JOPH2017-1847179.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/ab99839ac14f/JOPH2017-1847179.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/d0f18fb53565/JOPH2017-1847179.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/8b0a5a41da5b/JOPH2017-1847179.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/4730fdf536d9/JOPH2017-1847179.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/ab99839ac14f/JOPH2017-1847179.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/d0f18fb53565/JOPH2017-1847179.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/8b0a5a41da5b/JOPH2017-1847179.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa58/5523514/4730fdf536d9/JOPH2017-1847179.004.jpg

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