Joseph X, Balazs T
J Pharm Pharmacol. 1986 Sep;38(9):695-7. doi: 10.1111/j.2042-7158.1986.tb03113.x.
The cardiotoxic effects of hydralazine and prenalterol, given alone and in combination, were assessed in rats and rabbits. Acute myocardial necrosis was induced by a single administration of each drug alone in rats. However, the incidence and severity of lesions were markedly enhanced when both drugs were given in combination. Rats that received the same treatment for 10 consecutive days showed minimal or no acute necrosis, demonstrating the development of a resistance to further cardiotoxic effects of the drugs. Rabbits showed only minimal lesions when either drug was used alone and no enhancement of lesions when they were given in combination. From these data, it is concluded that the possibility of a cardiotoxic interaction exists when these drugs are used in combination and that the heavy rat (500-600 g) is a more sensitive model than the rabbit for studies of this nature.
在大鼠和兔子身上评估了单独使用和联合使用肼屈嗪与普瑞特罗的心脏毒性作用。在大鼠中，单独单次给予每种药物均可诱发急性心肌坏死。然而，当两种药物联合使用时，病变的发生率和严重程度明显增加。连续10天接受相同治疗的大鼠显示出最小程度的急性坏死或无急性坏死，表明对药物进一步的心脏毒性作用产生了抗性。单独使用任何一种药物时，兔子仅表现出最小程度的病变，联合使用时病变也没有加重。从这些数据可以得出结论，这些药物联合使用时存在心脏毒性相互作用的可能性，并且在这类研究中，体重较重的大鼠（500 - 600克）比兔子更敏感。
