Khan Inamullah, Waqas Muhammad, Shamim Muhammad Shahzad
Aga Khan University Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2017 Jul;67(7):1121-1123.
Multiple intraoperative aids have been introduced to improve the extent of resection (EOR) in Glioblastoma Multiforme (GBM) patients, avoiding any new neurological deficits. Intraoperative MRI (iMRI) has been debated for its utility and cost for nearly two decades in neurosurgical literature. Review of literature suggests improved EOR in GBM patients who underwent iMRI assisted surgical resections leading to higher overall survival (OS) and progression free survival (PFS). iMRI provides real time intraoperative imaging with reasonable quality. Higher risk for new postoperative deficits with increased EOR is not reported in any study using iMRI. The level of evidence regarding prognostic benefits of iMRI is still of low quality..
已经引入了多种术中辅助手段来提高多形性胶质母细胞瘤（GBM）患者的切除范围（EOR），同时避免出现任何新的神经功能缺损。术中磁共振成像（iMRI）在神经外科文献中因其效用和成本问题已经争论了近二十年。文献综述表明，接受iMRI辅助手术切除的GBM患者的EOR有所改善，从而提高了总生存期（OS）和无进展生存期（PFS）。iMRI可提供质量合理的实时术中成像。在任何使用iMRI的研究中，均未报告随着EOR增加而出现新的术后缺损的风险更高。关于iMRI预后益处的证据水平仍然较低。
