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基于胶原蛋白的3D打印聚己内酯/聚乳酸-羟基乙酸共聚物/β-磷酸三钙复合块状骨移植材料与双相磷酸钙骨替代物用于骨再生的比较疗效

Comparative Efficacies of Collagen-Based 3D Printed PCL/PLGA/β-TCP Composite Block Bone Grafts and Biphasic Calcium Phosphate Bone Substitute for Bone Regeneration.

作者信息

Hwang Kyoung-Sub, Choi Jae-Won, Kim Jae-Hun, Chung Ho Yun, Jin Songwan, Shim Jin-Hyung, Yun Won-Soo, Jeong Chang-Mo, Huh Jung-Bo

机构信息

Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea.

Department of Mechanical System Engineering, Graduate School of Knowledge-Based Technology and Energy, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea.

出版信息

Materials (Basel). 2017 Apr 17;10(4):421. doi: 10.3390/ma10040421.

DOI:10.3390/ma10040421
PMID:28772780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5506921/
Abstract

The purpose of this study was to compare bone regeneration and space maintaining ability of three-dimensional (3D) printed bone grafts with conventional biphasic calcium phosphate (BCP). After mixing polycaprolactone (PCL), poly (lactic-co-glycolic acid) (PLGA), and β-tricalcium phosphate (β-TCP) in a 4:4:2 ratio, PCL/PLGA/β-TCP particulate bone grafts were fabricated using 3D printing technology. Fabricated particulate bone grafts were mixed with atelocollagen to produce collagen-based PCL/PLGA/β-TCP composite block bone grafts. After formation of calvarial defects 8 mm in diameter, PCL/PLGA/β-TCP composite block bone grafts and BCP were implanted into bone defects of 32 rats. Although PCL/PLGA/β-TCP composite block bone grafts were not superior in bone regeneration ability compared to BCP, the results showed relatively similar performance. Furthermore, PCL/PLGA/β-TCP composite block bone grafts showed better ability to maintain bone defects and to support barrier membranes than BCP. Therefore, within the limitations of this study, PCL/PLGA/β-TCP composite block bone grafts could be considered as an alternative to synthetic bone grafts available for clinical use.

摘要

本研究的目的是比较三维（3D）打印骨移植材料与传统双相磷酸钙（BCP）的骨再生和空间维持能力。将聚己内酯（PCL）、聚（乳酸-乙醇酸）共聚物（PLGA）和β-磷酸三钙（β-TCP）按4:4:2的比例混合后，采用3D打印技术制备PCL/PLGA/β-TCP颗粒状骨移植材料。将制备好的颗粒状骨移植材料与去端胶原蛋白混合，制成基于胶原蛋白的PCL/PLGA/β-TCP复合块状骨移植材料。在形成直径为8mm的颅骨缺损后，将PCL/PLGA/β-TCP复合块状骨移植材料和BCP植入32只大鼠的骨缺损处。虽然PCL/PLGA/β-TCP复合块状骨移植材料在骨再生能力方面并不优于BCP，但结果显示其性能相对相似。此外，PCL/PLGA/β-TCP复合块状骨移植材料在维持骨缺损和支撑屏障膜方面比BCP表现更好。因此，在本研究的局限性范围内，PCL/PLGA/β-TCP复合块状骨移植材料可被视为临床可用合成骨移植材料的替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/c50a4ba0974d/materials-10-00421-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/7dd21bf8f782/materials-10-00421-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/7a0dc07b5ed1/materials-10-00421-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/c50a4ba0974d/materials-10-00421-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/eb10317f56a3/materials-10-00421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/5eeab14dc173/materials-10-00421-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/5556b3c8e92d/materials-10-00421-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/7dd21bf8f782/materials-10-00421-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18b/5506921/c50a4ba0974d/materials-10-00421-g010.jpg

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