Giuliani Alessandra, Manescu Adrian, Mohammadi Sara, Mazzoni Serena, Piattelli Adriano, Mangano Francesco, Iezzi Giovanna, Mangano Carlo
*Researcher, Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche, Sezione di Biochimica, Biologia e Fisica, Università Politecnica delle Marche, Ancona, Italy. †Research Fellow, Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche, Sezione di Biochimica, Biologia e Fisica, Università Politecnica delle Marche, Ancona, Italy. ‡Research Fellow, Elettra Sincrotrone Trieste S.C.p.A., Trieste, Italy; The Abdus Salam International Centre for Theoretical Physics, Trieste, Italy; and LAC1 USC Medical Center, Los Angeles, CA. §Professor of Oral Pathology and Medicine, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy. ¶Private Practice, Gravedona (Como), Italy. ‖Researcher, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy. #Private Practice, Gravedona (Como), Italy; and Visiting Professor of University of Chieti-Pescara, Department of Medical, Oral and Biotechnological Sciences, Chieti, Italy.
Implant Dent. 2016 Feb;25(1):6-15. doi: 10.1097/ID.0000000000000363.
Successful bone regeneration using both granules and blocks of biphasic calcium phosphate materials has been reported in the recent literature, in some clinical applications for maxillary sinus elevation, but the long-term kinetics of bone regeneration has still not been fully investigated.
Twenty-four bilateral sinus augmentation procedures were performed and grafted with hydroxyapatite/β-tricalcium phosphate 30/70, 12 with granules and 12 with blocks. The samples were retrieved at different time points and were evaluated for bone regeneration, graft resorption, neovascularization, and morphometric parameters by computed microtomography and histology.
A large amount of newly formed bone was detected in the retrieved specimens, together with a good rate of biomaterial resorption and the formation of a homogeneous and rich net of new vessels. The morphometric values were comparable at 5/6 months from grafting but, 9 months after grafting, revealed that the block-based specimens mimicked slightly better than granule-based samples the healthy native bone of the maxillary site.
The scaffold morphology was confirmed to influence the long-term kinetics of bone regeneration.
近期文献报道了在一些上颌窦提升的临床应用中，使用双相磷酸钙材料颗粒和块状物成功实现骨再生，但骨再生的长期动力学仍未得到充分研究。
进行了24例双侧鼻窦增高手术，并用羟基磷灰石/β-磷酸三钙30/70进行移植，其中12例用颗粒，12例用块状物。在不同时间点取出样本，通过计算机断层扫描和组织学评估骨再生、移植物吸收、新生血管形成和形态计量学参数。
在取出的标本中检测到大量新形成的骨，同时生物材料吸收良好，形成了均匀且丰富的新血管网络。移植后5/6个月时形态计量值相当，但移植9个月后，结果显示基于块状物的标本比基于颗粒的样本更能模拟上颌部位健康的天然骨。
证实支架形态会影响骨再生的长期动力学。
