Med J Aust. 1986 Nov 17;145(10):521-3.
The blood pressure of patients with hypertension who were aged between 60 and 75 years responded equally well to treatment with metoprolol (100 mg a day) or hydrochlorothiazide (25 mg a day) in a double-blind study which employed random allocation to two parallel groups. Drug-related variables other than blood pressure were used as markers of compliance. The resting heart rate alone discriminated substantially between the groups, but the discrimination was not increased by the inclusion of plasma potassium or plasma urate levels in the calculation. For the assessment of compliance, we suggest that greater use could be made of objective variables that are altered by drug treatment and are unrelated to the primary variable of interest in the study.
在一项双盲研究中，将年龄在60至75岁之间的高血压患者随机分为两个平行组，分别接受美托洛尔（每日100毫克）或氢氯噻嗪（每日25毫克）治疗，两组患者的血压对治疗的反应同样良好。除血压外，与药物相关的变量被用作依从性的指标。仅静息心率就能在两组之间产生显著差异，但在计算中纳入血钾或血尿酸水平后，这种差异并未增加。对于依从性的评估，我们建议更多地使用因药物治疗而改变且与研究中主要关注变量无关的客观变量。
