Baldwin S, Parker R S
Nutr Cancer. 1986;8(4):273-82. doi: 10.1080/01635588609513904.
In this study, the effects of dietary fat and selenium on the development of putative preneoplastic foci induced by aflatoxin B1 were examined. Rat hepatic gamma-glutamyl transpeptidase (GGT) activity, selenium-dependent glutathione peroxidase activity, glutathione, and total lipid were analyzed 3 and 13 weeks after the start of dietary and carcinogen treatment. Results indicate that high dietary fat has an enhancing effect on the development of preneoplastic foci. A high-fat, selenium-deficient diet resulted in an increase in foci development, but the increase was not significant. An interaction between aflatoxin and the two nutrients was also observed in liver glutathione content and GGT activity at Week 3.
在本研究中，检测了膳食脂肪和硒对黄曲霉毒素B1诱导的假定癌前病灶发展的影响。在开始膳食和致癌物处理后的3周和13周，分析了大鼠肝脏γ-谷氨酰转肽酶（GGT）活性、硒依赖性谷胱甘肽过氧化物酶活性、谷胱甘肽和总脂质。结果表明，高膳食脂肪对癌前病灶的发展有促进作用。高脂肪、缺硒饮食导致病灶发展增加，但增加不显著。在第3周时，还观察到黄曲霉毒素与这两种营养素之间在肝脏谷胱甘肽含量和GGT活性方面存在相互作用。
