Walsh D M
Pediatr Emerg Care. 1986 Mar;2(1):28-35. doi: 10.1097/00006565-198603000-00009.
Cyclic antidepressant overdose is a major cause of drug overdose deaths and morbidity in the United States. The cyclic antidepressants are prescribed widely by primary care physicians and psychiatrists, and accidental overdose in children is not uncommon. Children have exhibited toxic effects with relatively small amounts of cyclic antidepressants. The management of cyclic antidepressant overdose is difficult because of the complex effects on the cardiovascular and nervous systems. The pertinent pharmacology of cyclic antidepressants in therapeutic amounts and in overdose is reviewed in this article. The clinical manifestations of cyclic antidepressant overdose are described. A protocol for effective management of cyclic antidepressant overdose in children is proposed.
在美国，环性抗抑郁药过量是药物过量致死和发病的主要原因。环性抗抑郁药由初级保健医生和精神科医生广泛开出处方，儿童意外过量服用的情况并不罕见。儿童服用相对少量的环性抗抑郁药就会出现中毒效应。由于对心血管系统和神经系统的复杂影响，环性抗抑郁药过量的处理很困难。本文综述了治疗量和过量情况下环性抗抑郁药的相关药理学。描述了环性抗抑郁药过量的临床表现。提出了有效处理儿童环性抗抑郁药过量的方案。
