H2受体拮抗剂对大鼠部分肝切除术后或四氯化碳诱导的肝损伤后肝脏的影响。

Effects of H2-receptor antagonists on the rat liver after partial hepatectomy or carbon tetrachloride-induced hepatic injury.

作者信息

Lee S D, Wang J Y, Cho C H, Wu J C, Lu R H, Lai K H, Tsai Y T, Lo K J

出版信息

Scand J Gastroenterol. 1986 Oct;21(8):984-90. doi: 10.3109/00365528608996409.

Abstract

A total of 512 male rats were used to investigate the effects of H2-receptor antagonists on the liver after two-thirds hepatectomy or after carbon tetrachloride (CCl4)-induced hepatic injury. The serum aminotransferase levels in hepatectomy rats were significantly elevated as compared with those of rats with the sham operation 1 and 2 days after the operation. However, there were no differences in the serum aminotransferase levels and liver regeneration rates among the groups of hepatectomy rats who were treated with saline, cimetidine, or ranitidine. The injections of cimetidine or ranitidine did not induce a significant increase in serum amino-transferase levels or increase the severity of liver cell necrosis in CCl4-treated rats, as compared with the CCl4-treated rats who received saline injection. Thus, our data indicate that H2-receptor antagonists do not inhibit liver regeneration in rats after two-thirds hepatectomy or exert a detrimental effect on the liver cell necrosis in rats after CCl4-induced hepatic injury.

摘要

总共512只雄性大鼠被用于研究H2受体拮抗剂对三分之二肝切除术后或四氯化碳（CCl4）诱导的肝损伤后肝脏的影响。与假手术大鼠相比，肝切除大鼠术后1天和2天血清转氨酶水平显著升高。然而，在接受生理盐水、西咪替丁或雷尼替丁治疗的肝切除大鼠组中，血清转氨酶水平和肝脏再生率并无差异。与接受生理盐水注射的CCl4处理大鼠相比，注射西咪替丁或雷尼替丁并未导致CCl4处理大鼠血清转氨酶水平显著升高，也未增加肝细胞坏死的严重程度。因此，我们的数据表明，H2受体拮抗剂不会抑制大鼠三分之二肝切除术后的肝脏再生，也不会对CCl4诱导的肝损伤后大鼠的肝细胞坏死产生有害影响。