From the Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (J.P.C.); and Division of Vascular Surgery, Stanford University School of Medicine, CA (N.J.L.).
Circ Res. 2017 Aug 4;121(4):320-322. doi: 10.1161/CIRCRESAHA.117.311493.
Pericytes are vascular smooth muscle cells that stabilize the endothelial networks that comprise the microvasculature. There is increased interest in the role that these cells play in maintaining the architecture, permeability, and remodeling of the microvasculature. Furthermore, these cells may be a source of regenerative cells that participate in the response to injury and ischemia. Bischoff and colleagues have comprehensively characterized a novel determinant of pericyte function, and suggest its possible role in heart failure.
周细胞是血管平滑肌细胞，可稳定构成微血管的内皮网络。人们越来越关注这些细胞在维持微血管的结构、通透性和重塑方面所起的作用。此外，这些细胞可能是参与损伤和缺血反应的再生细胞的来源。Bischoff 及其同事全面描述了周细胞功能的一个新决定因素，并提出了其在心衰中的可能作用。
