Tytgat G N
Z Gastroenterol. 1986 Sep;24 Suppl 2:40-4.
The medical therapy of reflux esophagitis consists of modifications of the patients's lifestyle and antacids, alginic acid or both (phase I). Phase II medications include drugs that suppress acid/peptic activity (antacid/alginate, H2-receptor blockers, cimetidine, ranitidine, famotidine), drugs that enhance motility (metoclopramide, domperidone) and drugs that coat and increase mucosal protection (sucralfate). Combinations of H2-receptor blockers and motility stimulating drugs have not been very effective. Overall the results of medical therapy of reflux esophagitis are suboptimal.
反流性食管炎的药物治疗包括改变患者生活方式以及使用抗酸剂、海藻酸或两者并用（第一阶段）。第二阶段的药物包括抑制酸/消化活性的药物（抗酸剂/海藻酸盐、H2受体阻滞剂、西咪替丁、雷尼替丁、法莫替丁）、增强动力的药物（甲氧氯普胺、多潘立酮）以及覆盖并增强黏膜保护作用的药物（硫糖铝）。H2受体阻滞剂与促动力药物的联合使用效果并不十分理想。总体而言，反流性食管炎药物治疗的效果欠佳。
