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Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.

作者信息

Nguyen Hung V-T, Chen Qixian, Paletta Joseph T, Harvey Peter, Jiang Yivan, Zhang Hui, Boska Michael D, Ottaviani M Francesca, Jasanoff Alan, Rajca Andrzej, Johnson Jeremiah A

机构信息

Department of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States.

出版信息

ACS Cent Sci. 2017 Jul 26;3(7):800-811. doi: 10.1021/acscentsci.7b00253. Epub 2017 Jul 12.

DOI:10.1021/acscentsci.7b00253
PMID:28776023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5532724/
Abstract

Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI . Herein, we report nitroxide-functionalized brush-arm star polymer organic radical contrast agents (BASP-ORCAs) that overcome the low contrast and poor stability associated with nitroxide-based MRI contrast agents. As a consequence of their unique nanoarchitectures, BASP-ORCAs possess per-nitroxide transverse relaxivities up to ∼44-fold greater than common nitroxides, exceptional stability in highly reducing environments, and low toxicity. These features combine to provide for accumulation of a sufficient concentration of BASP-ORCA in murine subcutaneous tumors up to 20 h following systemic administration such that MRI contrast on par with metal-based agents is observed. BASP-ORCAs are, to our knowledge, the first nitroxide MRI contrast agents capable of tumor imaging over long time periods using clinical high-field H MRI techniques.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/fc5b3f8f6421/oc-2017-002534_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/108dfa9705d0/oc-2017-002534_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/78c389222b9b/oc-2017-002534_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/31b8de39c86f/oc-2017-002534_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/963f8c402887/oc-2017-002534_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/ab47f58e1c6f/oc-2017-002534_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/fc5b3f8f6421/oc-2017-002534_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/108dfa9705d0/oc-2017-002534_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/78c389222b9b/oc-2017-002534_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/31b8de39c86f/oc-2017-002534_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/963f8c402887/oc-2017-002534_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/ab47f58e1c6f/oc-2017-002534_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5532724/fc5b3f8f6421/oc-2017-002534_0006.jpg

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[1]
Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.

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[2]
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引用本文的文献

[1]
Novel non‑metal‑based contrast agents for MR imaging: Emerging approaches and clinical perspectives (Review).

Int J Oncol. 2025-8

[2]
Nitroxides: Chemistry, Antioxidant Properties, and Biomedical Applications.

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[3]
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[4]
Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles.

Chem Biomed Imaging. 2025-2-2

[5]
-/-Specific Synthesis of Functionalized Bottlebrush Ring Opening Metathesis Polymerization Polymers Containing Terthiophene and Pyrene That Exhibit Unique Thermal and Emission Properties.

ACS Macro Lett. 2025-3-18

[6]
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[7]
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ACS Appl Mater Interfaces. 2024-11-27

[8]
Modulation of the Human Erythrocyte Antioxidant System by the 5- and 6-Membered Heterocycle-Based Nitroxides.

Molecules. 2024-6-20

[9]
Contrast Agents Based on Human Serum Albumin and Nitroxides for H-MRI and Overhauser-Enhanced MRI.

Int J Mol Sci. 2024-4-5

[10]
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J Nanobiotechnology. 2023-12-21

本文引用的文献

[1]
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents.

Proc Natl Acad Sci U S A. 2017-2-28

[2]
One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents.

ACS Nano. 2017-1-11

[3]
Nanomaterials for In Vivo Imaging.

Chem Rev. 2017-1-3

[4]
Clinically Approved Nanoparticle Imaging Agents.

J Nucl Med. 2016-12

[5]
Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity.

J Am Chem Soc. 2016-9-14

[6]
Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy.

J Control Release. 2016-7-14

[7]
A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy.

Nat Nanotechnol. 2016-5-16

[8]
Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas.

Nano Lett. 2016-4-20

[9]
Safety and technique of ferumoxytol administration for MRI.

Magn Reson Med. 2016-5

[10]
Increases in Anthropogenic Gadolinium Anomalies and Rare Earth Element Concentrations in San Francisco Bay over a 20 Year Record.

Environ Sci Technol. 2016-4-19

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