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60 years of metformin use: a glance at the past and a look to the future.

作者信息

Marshall Sally M

机构信息

Diabetes Research Group, Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

出版信息

Diabetologia. 2017 Sep;60(9):1561-1565. doi: 10.1007/s00125-017-4343-y.

DOI:10.1007/s00125-017-4343-y
PMID:28776085
Abstract
摘要

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The mechanisms of action of metformin.二甲双胍的作用机制。
Diabetologia. 2017 Sep;60(9):1577-1585. doi: 10.1007/s00125-017-4342-z. Epub 2017 Aug 3.
2
Metformin: historical overview.二甲双胍:历史概述。
Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3.
3
Repurposing metformin for the prevention of cancer and cancer recurrence.二甲双胍的再利用:预防癌症和癌症复发。
Curr Pharm Des. 2025 Apr 8. doi: 10.2174/0113816128367242250214052019.
4
Association of metformin administration with the serum levels of zinc and homocysteine in patients with type 2 diabetes: a cross-sectional study.二甲双胍给药与2型糖尿病患者血清锌和同型半胱氨酸水平的关联:一项横断面研究。
Diabetol Int. 2025 Feb 8;16(2):394-402. doi: 10.1007/s13340-025-00798-x. eCollection 2025 Apr.
5
Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits.线粒体与糖尿病药物的重新利用以获得非标签健康益处
Int J Mol Sci. 2025 Jan 3;26(1):364. doi: 10.3390/ijms26010364.
6
Single-cell RNA transcriptomics in mice reveals embryonic origin of fibrosis due to maternal obesity.单细胞 RNA 转录组学在小鼠中揭示了母体肥胖导致纤维化的胚胎起源。
EBioMedicine. 2024 Nov;109:105421. doi: 10.1016/j.ebiom.2024.105421. Epub 2024 Oct 30.
7
Hymecromone Promotes Longevity and Insulin Sensitivity in Mice.槐定碱可延长小鼠寿命并提高其胰岛素敏感性。
Cells. 2024 Oct 18;13(20):1727. doi: 10.3390/cells13201727.
8
Energy Metabolism and Metformin: Effects on Ischemia-Reperfusion Injury in Kidney Transplantation.能量代谢与二甲双胍:对肾移植缺血再灌注损伤的影响
Biomedicines. 2024 Jul 10;12(7):1534. doi: 10.3390/biomedicines12071534.
9
Metformin Effects on SHIP2, AMPKs and Gut Microbiota: Recent Updates on Pharmacology.二甲双胍对SHIP2、AMPK和肠道微生物群的影响:药理学最新进展
Curr Med Chem. 2025;32(9):1732-1754. doi: 10.2174/0109298673289342240213040144.
10
Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression.2 型糖尿病进展中的线粒体功能障碍、氧化应激和器官间通讯失调。
Int J Mol Sci. 2024 Jan 25;25(3):1504. doi: 10.3390/ijms25031504.
Diabetologia. 2017 Sep;60(9):1639-1647. doi: 10.1007/s00125-017-4372-6. Epub 2017 Aug 3.
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The pharmacogenetics of metformin.二甲双胍的药物遗传学。
Diabetologia. 2017 Sep;60(9):1648-1655. doi: 10.1007/s00125-017-4335-y. Epub 2017 Aug 3.
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Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome.二甲双胍治疗多囊卵巢综合征的生殖和代谢后果。
Diabetologia. 2017 Sep;60(9):1656-1661. doi: 10.1007/s00125-017-4306-3. Epub 2017 Aug 3.
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Metformin and ageing: improving ageing outcomes beyond glycaemic control.二甲双胍与衰老:改善血糖控制之外的衰老结局。
Diabetologia. 2017 Sep;60(9):1630-1638. doi: 10.1007/s00125-017-4349-5. Epub 2017 Aug 2.
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A new perspective on metformin therapy in type 1 diabetes.二甲双胍治疗 1 型糖尿病的新视角。
Diabetologia. 2017 Sep;60(9):1594-1600. doi: 10.1007/s00125-017-4364-6. Epub 2017 Aug 2.
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The effects of metformin on gut microbiota and the immune system as research frontiers.二甲双胍对肠道微生物群和免疫系统影响的研究前沿。
Diabetologia. 2017 Sep;60(9):1662-1667. doi: 10.1007/s00125-017-4352-x. Epub 2017 Aug 2.
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Metformin use in pregnancy: promises and uncertainties.孕期使用二甲双胍:前景可期,仍存疑问。
Diabetologia. 2017 Sep;60(9):1612-1619. doi: 10.1007/s00125-017-4351-y. Epub 2017 Aug 2.
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Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes.二甲双胍对心血管疾病的影响:一项对 2 型糖尿病患者随机试验的荟萃分析。
Diabetologia. 2017 Sep;60(9):1620-1629. doi: 10.1007/s00125-017-4337-9. Epub 2017 Aug 2.