Int J Public Health. 2018 May;63(Suppl 1):109-121. doi: 10.1007/s00038-017-1008-z. Epub 2017 Aug 3.
Diarrheal diseases (DD) are an important cause of disease burden, especially in children in low-income settings. DD can also impact children's potential livelihood through growth faltering, cognitive impairment, and other sequelae.
As part of the Global Burden of Disease study, we estimated DD burden, and the burden attributable to specific risk factors and etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2015. We calculated disability-adjusted life-years (DALYs)-the sum of years of life lost and years lived with disability-for both sexes and all ages.
We estimate that over 103,692 diarrhea deaths occurred in the EMR in 2015 (95% uncertainty interval: 87,018-124,692), and the mortality rate was 16.0 deaths per 100,000 persons (95% UI: 13.4-19.2). The majority of these deaths occurred in children under 5 (63.3%) (65,670 deaths, 95% UI: 53,640-79,486). DALYs per 100,000 ranged from 304 (95% UI 228-400) in Kuwait to 38,900 (95% UI 25,900-54,300) in Somalia.
Our findings will guide evidence-based health policy decisions for interventions to achieve the ultimate goal of reducing the DD burden.
腹泻病（DD）是疾病负担的一个重要原因，尤其是在低收入环境中的儿童。DD 还会通过生长迟缓、认知障碍和其他后遗症影响儿童的潜在生计。
作为全球疾病负担研究的一部分，我们估计了 1990 年至 2015 年期间东地中海区域（EMR）的腹泻病负担，以及特定风险因素和病因造成的负担。我们计算了残疾调整生命年（DALY）-即生命损失年数和失能生存年数的总和-适用于所有性别和所有年龄组。
我们估计，2015 年 EMR 有超过 103692 人死于腹泻（95%不确定区间：87018-124692），死亡率为每 10 万人 16.0 人死亡（95% UI：13.4-19.2）。这些死亡大多发生在 5 岁以下儿童中（63.3%）（65670 人死亡，95% UI：53640-79486）。每 10 万人的 DALY 范围从科威特的 304（95% UI 228-400）到索马里的 38900（95% UI 25900-54300）。
我们的研究结果将为实现减少腹泻病负担的最终目标而采取的干预措施提供循证卫生政策决策依据。
