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1
The history and development of N-of-1 trials.单病例试验的历史与发展。
J R Soc Med. 2017 Aug;110(8):330-340. doi: 10.1177/0141076817721131.
2
[The clinical trial: experiment of clinical medicine].[临床试验：临床医学实验]
Cir Pediatr. 2006 Jul;19(3):121-2.
3
Commentary for history special issue of Research Synthesis Methods.《研究综合方法》历史特刊评论
Res Synth Methods. 2015 Sep;6(3):268-71. doi: 10.1002/jrsm.1144. Epub 2015 Jun 10.
4
Form meets function: A commentary on meta-analytic history.形式与功能：对元分析历史的评论
Res Synth Methods. 2015 Sep;6(3):290-2. doi: 10.1002/jrsm.1141. Epub 2015 Jun 10.
5
Some reflections on the evolution of meta-analysis.对荟萃分析演变的一些思考。
Res Synth Methods. 2015 Sep;6(3):265-7. doi: 10.1002/jrsm.1156.
6
We know less than we should about methods of meta-analysis.我们对荟萃分析方法的了解比我们应该了解的要少。
Res Synth Methods. 2015 Sep;6(3):287-9. doi: 10.1002/jrsm.1146. Epub 2015 Jun 10.
7
"Opinions differ significantly": Early experiences with meta-analysis and the people who made it possible.“观点差异显著”：元分析的早期经验及使之成为可能的人们。
Res Synth Methods. 2015 Sep;6(3):272-6. doi: 10.1002/jrsm.1142. Epub 2015 Jun 10.
8
[Clinical trial under trial. 'Trial and error'].
Pharm Weekbl Sci. 1983 Feb 25;5(1):1-8. doi: 10.1007/BF01959644.
9
Do we learn the right things from clinical trials?我们从临床试验中学到了正确的东西吗？
Eur J Clin Pharmacol. 2008 Feb;64(2):115-25. doi: 10.1007/s00228-007-0411-4. Epub 2008 Jan 29.
10
Therapeutic Proofs and Medical Truths: The Enduring Legacy of Early Modern Drug Trials.治疗证据与医学真理：早期现代药物试验的持久遗产。
Bull Hist Med. 2017;91(2):420-429. doi: 10.1353/bhm.2017.0032.

引用本文的文献

1
Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies.单基因癫痫中应用超说明书精准治疗的临床单病例N-of-1策略蓝图。
Orphanet J Rare Dis. 2025 Jun 16;20(1):309. doi: 10.1186/s13023-025-03750-z.
2
N-of-1 tests in general practice: pharmacological considerations.全科医疗中的单病例试验：药理学考量
Br J Gen Pract. 2025 Feb 27;75(752):132-135. doi: 10.3399/bjgp25X740985. Print 2025 Mar.
3
A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies.个性化治疗的开发、管理与评估的概念模型及实践指南。
Front Med (Lausanne). 2025 Jan 24;12:1493832. doi: 10.3389/fmed.2025.1493832. eCollection 2025.
4
The role of single case experimental designs in evidence creation in rehabilitation.单病例实验设计在康复证据生成中的作用。
Eur J Phys Rehabil Med. 2024 Dec;60(6):1100-1111. doi: 10.23736/S1973-9087.24.08713-6. Epub 2024 Oct 7.
5
Uncovering individualised treatment effects for educational trials.揭示教育试验中的个体化治疗效果。
Sci Rep. 2024 Sep 30;14(1):22606. doi: 10.1038/s41598-024-73714-z.
6
A methodological review of randomised n-of-1 trials.随机 n-of-1 试验的方法学综述。
Trials. 2024 Apr 16;25(1):263. doi: 10.1186/s13063-024-08100-1.
7
Analyzing population-level trials as N-of-1 trials: An application to gait.将群体水平试验作为单病例试验进行分析：在步态研究中的应用。
Contemp Clin Trials Commun. 2024 Feb 29;38:101282. doi: 10.1016/j.conctc.2024.101282. eCollection 2024 Apr.
8
A qualitative study on the facilitators and barriers to adopting the N-of-1 trial methodology as part of clinical practice: potential versus implementation challenges.一项关于采用单病例试验方法作为临床实践一部分的促进因素和障碍的定性研究：潜在挑战与实施挑战。
Int J Qual Stud Health Well-being. 2024 Dec;19(1):2318810. doi: 10.1080/17482631.2024.2318810. Epub 2024 Feb 28.
9
N-of-1 Trials, Their Reporting Guidelines, and the Advancement of Open Science Principles.单病例试验、其报告指南及开放科学原则的推进。
Harv Data Sci Rev. 2022;4(SI3). doi: 10.1162/99608f92.a65a257a. Epub 2022 Sep 8.
10
Introducing Data Sciences to N-of-1 Designs, Statistics, Use-Cases, the Future, and the Moniker 'N-of-1' Trial.将数据科学引入单病例设计、统计学、用例、未来以及“单病例”试验这一名称。
Harv Data Sci Rev. 2022;4(SI3). doi: 10.1162/99608f92.116c43fe. Epub 2022 Sep 8.

本文引用的文献

1
The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement.《行为干预单病例报告指南（SCRIBE）2016声明》
Aphasiology. 2016 Jul 2;30(7):862-876. doi: 10.1080/02687038.2016.1178022. Epub 2016 Apr 29.
2
N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis.单病例试验可汇总以生成组平均治疗效果：一项系统评价和荟萃分析。
J Clin Epidemiol. 2016 Aug;76:65-75. doi: 10.1016/j.jclinepi.2016.03.026. Epub 2016 Apr 20.
3
N-of-1 trials are a tapestry of heterogeneity.单病例试验是异质性的交织。
J Clin Epidemiol. 2016 Aug;76:47-56. doi: 10.1016/j.jclinepi.2016.03.023. Epub 2016 Apr 11.
4
To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD.是否进行荟萃分析？对苯丙胺和哌甲酯治疗儿童注意力缺陷多动障碍的单病例试验数据与随机对照试验数据进行联合荟萃分析。
J Clin Epidemiol. 2016 Aug;76:76-81. doi: 10.1016/j.jclinepi.2016.03.021. Epub 2016 Apr 7.
5
Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review.1985年至2013年间发表的单病例随机对照试验的报告质量：一项系统评价。
J Clin Epidemiol. 2016 Aug;76:57-64. doi: 10.1016/j.jclinepi.2015.11.016. Epub 2016 Jan 6.
6
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement.用于报告单病例试验（CENT）的CONSORT扩展版2015声明。
J Clin Epidemiol. 2016 Aug;76:9-17. doi: 10.1016/j.jclinepi.2015.05.004. Epub 2015 Aug 10.
7
CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration.报告单病例试验（CENT）的CONSORT扩展版2015：解释与详述。
J Clin Epidemiol. 2016 Aug;76:18-46. doi: 10.1016/j.jclinepi.2015.05.018. Epub 2015 Aug 10.
8
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement.报告单病例试验（CENT）的CONSORT扩展版2015声明。
BMJ. 2015 May 14;350:h1738. doi: 10.1136/bmj.h1738.
9
Personalized medicine: Time for one-person trials.个性化医疗：单人试验的时代。
Nature. 2015 Apr 30;520(7549):609-11. doi: 10.1038/520609a.
10
The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial.PREEMPT研究——评估智能手机辅助的慢性疼痛患者单病例试验：一项随机对照试验的研究方案。
Trials. 2015 Feb 27;16:67. doi: 10.1186/s13063-015-0590-8.

The history and development of N-of-1 trials.

作者信息

Mirza R D, Punja S, Vohra S, Guyatt G

机构信息

1 Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8 Ontario, Canada.

2 Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3 Alberta, Canada.

出版信息

J R Soc Med. 2017 Aug;110(8):330-340. doi: 10.1177/0141076817721131.

DOI:10.1177/0141076817721131
PMID:28776473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5546658/
Abstract
摘要