Hoya Satoshi, Watanabe Yuichiro, Shibuya Masako, Someya Toshiyuki
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Department of Psychiatry, Uonuma Institute of Community Medicine, Niigata University Graduate School of Medical and Dental Hospital, Niigata, Japan.
Early Interv Psychiatry. 2018 Oct;12(5):938-941. doi: 10.1111/eip.12472. Epub 2017 Aug 4.
Two single-nucleotide polymorphisms, rs3828611 and rs4704591, in the cardiomyopathy-associated protein 5 (CMYA5) gene have been extensively investigated for associations with schizophrenia in Asian populations, but with conflicting results. To assess the collective evidence across individual studies, we conducted an updated meta-analysis.
We performed a random-effect model meta-analysis of the associations of rs3828611 and rs4704591 with schizophrenia using seven case-control samples from Asian populations (8074 patients and 8139 controls).
The meta-analysis indicated that rs3828611 and rs4704591 were not significantly associated with schizophrenia (odds ratios [OR] = 0.93, 95% confidence interval [CI] = 0.85-1.01 and OR = 0.99, 95% CI = 0.93-1.05, respectively).
Our meta-analysis did not provide evidence supporting a contribution of CMYA5 rs3828611 and rs4704591 to schizophrenia susceptibility in Asian populations.
心肌病相关蛋白5（CMYA5）基因中的两个单核苷酸多态性rs3828611和rs4704591与亚洲人群精神分裂症的关联已得到广泛研究，但结果相互矛盾。为评估个体研究的综合证据，我们进行了一项更新的荟萃分析。
我们使用来自亚洲人群的7个病例对照样本（8074例患者和8139例对照），对rs3828611和rs4704591与精神分裂症的关联进行了随机效应模型荟萃分析。
荟萃分析表明，rs3828611和rs4704591与精神分裂症无显著关联（优势比[OR]分别为0.93，95%置信区间[CI]=0.85-1.01和OR=0.99，95%CI=0.93-1.05）。
我们的荟萃分析没有提供证据支持CMYA5基因的rs3828611和rs4704591对亚洲人群精神分裂症易感性有影响。
