Sahin Hulya, Varol Yelda, Naz Ilknur, Tuksavul Fevziye
Pulmonary Rehabilitation Unit, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey.
Department of Chest Diseases, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey.
Clin Respir J. 2018 Apr;12(4):1439-1446. doi: 10.1111/crj.12680. Epub 2017 Aug 13.
It has been demonstrated that long-term oxygen therapy increased exercise capacity, improved the quality of life, reduced hospitalization and increased life expectancy in chronic hypoxemic COPD patients. The present study aims to evaluate the effectiveness of pulmonary rehabilitation (PR) in COPD patients receiving long-term oxygen therapy (LTOT) compared to COPD patients not receiving LTOT.
Chronic hypoxemic COPD patients using LTOT (LTOT group) and COPD patients not receiving LTOT (non-LTOT group) who participated in this study underwent a comprehensive 8-week outpatient PR program.
Twenty-seven out of 61 severe/very severe cases with COPD received LTOT at home, and 34 did not. After PR, 6-minute walking distance (6mWD) increased significantly and perceived dyspnea decreased significantly in both groups (P < .001, both). This change was significantly higher in the LTOT-receiving group compared to the non-LTOT Group (P = .046, P = .012). In both groups, all items in the disease-related quality of life questionnaire (QoL) were improved, and the scores in the health-related QoL questionnaire exhibited an improvement (P < .05, for all). Anxiety and depression scores were significantly lowered in both groups (P < .05, both).
Those COPD patients receiving the LTOT benefited from the PR as much as those COPD patients not receiving LTOT. The former group had a higher increase in 6mWD and a higher reduction in dyspnea symptoms. Further studies are required to understand to what extent the severe chronic hypoxemic COPD patients could benefit from the PR.
业已证明，长期氧疗可提高慢性低氧性慢性阻塞性肺疾病（COPD）患者的运动能力，改善生活质量，减少住院次数并延长预期寿命。本研究旨在评估长期氧疗（LTOT）的COPD患者与未接受LTOT的COPD患者相比，肺康复（PR）的有效性。
参与本研究的使用LTOT的慢性低氧性COPD患者（LTOT组）和未接受LTOT的COPD患者（非LTOT组）接受了为期8周的全面门诊PR计划。
61例重度/极重度COPD病例中，27例在家中接受LTOT，34例未接受。PR后，两组的6分钟步行距离（6mWD）均显著增加，呼吸困难感知均显著降低（均P <.001）。与非LTOT组相比，接受LTOT的组的这种变化显著更高（P = .046，P = .012）。两组中，疾病相关生活质量问卷（QoL）中的所有项目均得到改善，健康相关QoL问卷中的得分也有所提高（均P <.05）。两组的焦虑和抑郁评分均显著降低（均P <.05）。
接受LTOT的COPD患者与未接受LTOT的COPD患者从PR中获益程度相同。前一组的6mWD增加更高，呼吸困难症状减轻更明显。需要进一步研究以了解重度慢性低氧性COPD患者可从PR中获益的程度。
