α2-肾上腺素能受体激动剂对大鼠离体胃黏膜电场刺激酸分泌反应的影响。
The effect of alpha 2-adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation.
作者信息
Dettmar P W, Lord J A
出版信息
Br J Pharmacol. 1986 Oct;89(2):361-6. doi: 10.1111/j.1476-5381.1986.tb10268.x.
The effects of clonidine, UK-14,304, noradrenaline, para-aminoclonidine and phenylephrine were examined on the acid secretory response of the rat isolated gastric mucosa preparation to electrical field stimulation. Clonidine, UK-14,304, noradrenaline and para-aminoclonidine but not phenylephrine (10 microM) reduced the response of the gastric mucosa stimulated at 2.5 Hz; gastric mucosae stimulated at higher frequencies were insensitive to the action of these alpha 2-adrenoceptor agonists. The inhibitory effect of the selective alpha 2-adrenoceptor agonist UK-14,304 was antagonized by idazoxan but not by prazosin. These findings indicate that clonidine and other alpha 2-adrenoceptor agents inhibit the acid secretory response of the rat gastric mucosa to electrical field stimulation by an action at alpha 2-adrenoceptors, which are probably located on cholinergic nerve terminals.
研究了可乐定、UK-14,304、去甲肾上腺素、对氨基可乐定和去氧肾上腺素对大鼠离体胃黏膜标本电场刺激引起的胃酸分泌反应的影响。可乐定、UK-14,304、去甲肾上腺素和对氨基可乐定可降低胃黏膜在2.5 Hz刺激频率下的反应；而较高刺激频率下的胃黏膜对这些α2肾上腺素能受体激动剂的作用不敏感。选择性α2肾上腺素能受体激动剂UK-14,304的抑制作用可被咪唑克生拮抗，但不能被哌唑嗪拮抗。这些发现表明，可乐定和其他α2肾上腺素能药物通过作用于可能位于胆碱能神经末梢的α2肾上腺素能受体，抑制大鼠胃黏膜对电场刺激的胃酸分泌反应。
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