University of Basel , Department of Chemistry, Klingelbergstrasse 80, 4056 Basel, Switzerland.
Biomacromolecules. 2017 Nov 13;18(11):3471-3480. doi: 10.1021/acs.biomac.7b00764. Epub 2017 Aug 10.
The design of functional systems with sizes in the nanometer range is a key challenge in fields such as biomedicine, nanotechnology, and engineering. Some of the most promising materials nowadays consist of self-assembling peptides or peptide-polymer hybrid materials because of their versatility and the resulting properties that can be achieved with these structures. Self-assembly of pure amphiphilic peptides or in combination with block copolymers results in a large variety of nanostructures (micelles, nanoparticles (NPs), compartments, planar membranes) each with different characteristics and tunable properties. Here, we describe such novel peptide- or peptide-polymer-based supramolecular nanostructures and emphasize their functionality and various promising applications.
具有纳米级尺寸的功能系统的设计是生物医药、纳米技术和工程等领域的关键挑战。由于其多功能性以及可以通过这些结构实现的特性，当今一些最有前途的材料由自组装肽或肽-聚合物杂化材料组成。纯两亲性肽的自组装或与嵌段共聚物的组合导致了各种纳米结构（胶束、纳米粒子（NPs）、隔室、平面膜）的形成，每种结构都具有不同的特性和可调的性质。在这里，我们描述了这种新型的基于肽或肽-聚合物的超分子纳米结构，并强调了它们的功能和各种有前途的应用。
