School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China.
Chem Soc Rev. 2012 Sep 21;41(18):5986-97. doi: 10.1039/c2cs35130g. Epub 2012 Jul 13.
Self-assembly of amphiphilic hyperbranched polymers (HBPs) is a newly emerging research area and has attracted increasing attention due to the great advantages in biomedical applications. This tutorial review focuses on the self-assembly of biocompatible or biodegradable amphiphilic HBPs and their cytomimetic applications, and specialities or advantages therein owing to the hyperbranched structure have also been summarized. As shown here, various supramolecular structures including micelles, vesicles, tubes, fibers and films have been prepared through the primary self-assembly processes. The primary self-assemblies can be further assembled into more complex structures through hierachical self-assembly processes. Besides, the hyperbranched polymer vesicles have demonstrated great potential to be used as model membranes to mimic cellular behaviors, such as fusion, fission and cell aggregation. Other biomedical applications of HBPs as well as their self-assemblies are also briefly summarized.
两亲超支化聚合物的自组装是一个新兴的研究领域，由于其在生物医学应用中的巨大优势，引起了越来越多的关注。本综述重点介绍了生物相容性或可生物降解的两亲超支化聚合物的自组装及其细胞模拟应用，并且由于超支化结构的特殊性或优势也进行了总结。如图所示，通过初步的自组装过程可以制备各种超分子结构，包括胶束、囊泡、管、纤维和薄膜。通过层次自组装过程，初步自组装可以进一步组装成更复杂的结构。此外，超支化聚合物囊泡已被证明具有作为模型膜模拟细胞行为的巨大潜力，如融合、裂变和细胞聚集。超支化聚合物及其自组装在其他生物医学应用方面也进行了简要总结。
