Norton S W, Stockman J A
J Pediatr Ophthalmol Strabismus. 1979 May-Jun;16(3):190-3. doi: 10.3928/0191-3913-19790501-15.
Two subjects with acute lymphatic leukemia have been observed to have unilateral optic neuropathy five to seven days following administration of Vincristine (2.0 mg/sq m) during maintenance chemotherapy. Both subjects were in mission at the time their ocular problems developed. After discontinuance of Vincristine therapy, marked vision improvement in the affected eye occurred over the ensuing months. It is presumed that Vincristine therapy was the cause of toxic optic neuropathy in these patients.
两名急性淋巴细胞白血病患者在维持化疗期间接受长春新碱（2.0mg/平方米）治疗后五至七天出现单侧视神经病变。两名患者眼部问题出现时均在执行任务。停用长春新碱治疗后，患眼视力在接下来的几个月里有显著改善。据推测，长春新碱治疗是这些患者中毒性视神经病变的病因。
