Metz U, Graben N, Maruhn D, Bock K D
Clin Chim Acta. 1986 Oct 31;160(2):151-5. doi: 10.1016/0009-8981(86)90136-1.
2 g phenacetin or paracetamol in a single oral dose were administered to five healthy persons under the conditions of antidiuresis and subsequent water diuresis. Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics. Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol. The state of diuresis appeared to have no influence.
在抗利尿及随后的水利尿条件下，给5名健康人单次口服2克非那西丁或对乙酰氨基酚。在服用镇痛药之前、期间及之后，分析了刷状缘酶γ-谷氨酰转移酶（GGT）、细胞质酶乳酸脱氢酶（LDH）以及溶酶体酶N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和β-半乳糖苷酶（GAL）的排泄情况。LDH和GGT排泄增加表明非那西丁和对乙酰氨基酚之后肾小管上皮有类似程度的中度损伤。利尿状态似乎没有影响。
