Rojas-Ramírez Camila, Kramer-Urrutia Tomás, Cifuentes Lorena
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Email:
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave. 2017 Mar 24;17(Suppl1):e6873. doi: 10.5867/medwave.2017.6873.
Acute bacterial tonsillopharyngitis in children has been classically treated with long courses of antibiotic, usually 10 days, with the intention to prevent the occurrence of complications. However, it has not been clarified whether a shortened treatment could be equally effective in fulfilling that purpose. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified five systematic reviews including 59 randomized trials overall. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded that a shortened antibiotic regimen is probably similar, or with minimal differences, to a longer course, and might not make any difference regarding complications related to Streptococcus group A infection.
儿童急性细菌性扁桃体咽炎传统上采用较长疗程的抗生素治疗，通常为10天，目的是预防并发症的发生。然而，缩短疗程是否能同样有效地实现这一目的尚未明确。为回答这个问题，我们在由多个数据库筛选维护的Epistemonikos数据库中进行了检索。我们识别出五项系统评价，总共纳入了59项随机试验。我们提取数据、进行荟萃分析，并采用GRADE方法生成了结果总结表。我们得出结论，缩短抗生素疗程可能与较长疗程相似，或差异极小，并且在与A组链球菌感染相关的并发症方面可能没有任何差异。
