Department of Dermatology, University of Wisconsin, 1 South Park Street, 7th Floor, Madison, WI 53715, USA.
UCSF School of Medicine, 505 Parnassus Avenue, San Francisco, CA 94143, USA.
Obstet Gynecol Clin North Am. 2017 Sep;44(3):475-492. doi: 10.1016/j.ogc.2017.05.007.
Vulvovaginal chronic graft-versus-host disease (cGVHD) is an underrecognized complication of stem cell transplantation. Early recognition may prevent severe sequelae. Genital involvement is associated with oral, ocular, and skin manifestations. Treatment includes topical immunosuppression, dilator use, and adjuvant topical estrogen. Clinical and histologic features may mimic other inflammatory vulvar conditions. In the right clinical context, these findings are diagnostic of chronic GVHD. Female recipients of allo-hematopoietic stem cell transplantation (HCT) are at higher risk of condylomas, cervical dysplasia, and neoplasia. The National Institutes of Health publishes guidelines for the diagnosis, grading, management, and supportive care for HCT patients by organ system.
外阴阴道慢性移植物抗宿主病（cGVHD）是干细胞移植的一种未被充分认识的并发症。早期识别可能预防严重的后遗症。生殖器受累与口腔、眼部和皮肤表现有关。治疗包括局部免疫抑制、扩张器使用和辅助局部雌激素。临床和组织学特征可能类似于其他炎症性外阴疾病。在适当的临床背景下，这些发现可诊断为慢性 GVHD。异基因造血干细胞移植（HCT）的女性受者发生尖锐湿疣、宫颈发育不良和肿瘤的风险更高。美国国立卫生研究院（NIH）按器官系统发布了 HCT 患者的诊断、分级、管理和支持治疗指南。
